Albers C, Usinger W, Scholand C
Respir Physiol. 1975 Jan;23(1):59-70. doi: 10.1016/0034-5687(75)90072-9.
Intracellular pH, arterial blood gases and several plasma enzymes were estimated in unanesthetized dogs during a 3-hour exposure to 30 degrees C/50% relative humidity, and 40 degrees C/50% relative humidity. No change occurred during mild heat stress, whereas during severe heat stress a profound respiratory alkalosis developed together with an increase in intracellular pH from 7.03 to 7.29. Most plasma enzymes increased by about 300% or more. In spite of extreme panting body temperature rose to 42.2 degrees C. Exposure to 40 degrees C/50% relative humidity with 4% CO2 in the climatic chamber inhibited the respiratory alkalosis and the increase of plasma enzymes. Though the panting frequency was lower the ventilatory heat dissipation was more efficient. Body temperature rose to only 39.8 degrees C. It is concluded that the intracellular buffering is not able to prevent marked changes of the intracellular pH during panting.
在未麻醉的犬类中，于30摄氏度/50%相对湿度以及40摄氏度/50%相对湿度的环境下暴露3小时，期间对细胞内pH值、动脉血气和几种血浆酶进行了评估。轻度热应激期间未发生变化，而在重度热应激期间，出现了严重的呼吸性碱中毒，同时细胞内pH值从7.03升至7.29。大多数血浆酶增加了约300%或更多。尽管剧烈喘气，体温仍升至42.2摄氏度。在气候舱中暴露于40摄氏度/50%相对湿度并含有4%二氧化碳的环境下，抑制了呼吸性碱中毒和血浆酶的增加。虽然喘气频率较低，但通风散热更有效。体温仅升至39.8摄氏度。结论是，细胞内缓冲无法防止喘气期间细胞内pH值的显著变化。
