Department of Pharmaceutical Technology, Ege University, Izmir, Turkey.
Cancer Biother Radiopharm. 2013 Sep;28(7):530-3. doi: 10.1089/cbr.2012.1428. Epub 2013 May 9.
In this study, a microemulsion system was evaluated for delivery of mitomycin C (MMC). To track the distribution of the formulated drug after intravenous administration, radiochemical labeling and gamma scintigraphy imaging were used. The aim was to evaluate a microemulsion system for intravenous delivery of MMC and to compare its in vivo behavior with that of the MMC solution. For microemulsion formulation, soybean oil was used as the oil phase. Lecithin and Tween 80 were surfactants and ethanol was the cosurfactant. To understand the whole body localization of MMC-loaded microemulsion, MMC was labeled with radioactive technetium and gamma scintigraphy was applied for visualization of drug distribution. Radioactivity in the bladder 30 minutes after injection of the MMC solution was observed, according to static gamma camera images. This shows that urinary excretion of the latter starts very soon. On the other hand, no radioactivity appeared in the urinary bladder during the 90 minutes following the administration of MMC-loaded microemulsion. The unabated radioactivity in the liver during the experiment shows that the localization of microemulsion formulation in the liver is stable. In the light of the foregoing, it is suggested that this microemulsion formulation may be an appropriate carrier system for anticancer agents by intravenous delivery in hepatic cancer chemotherapy.
在这项研究中，评估了一种微乳液系统以递送丝裂霉素 C (MMC)。为了跟踪静脉给药后配制药物的分布，使用放射性化学标记和伽马闪烁成像进行了研究。目的是评估一种用于静脉递送 MMC 的微乳液系统，并将其体内行为与 MMC 溶液进行比较。对于微乳液制剂，使用大豆油作为油相。卵磷脂和吐温 80 用作表面活性剂，乙醇用作助表面活性剂。为了了解载有 MMC 的微乳液的全身定位，用放射性锝标记 MMC，并应用伽马闪烁成像来可视化药物分布。根据静态伽玛相机图像，观察到注射 MMC 溶液后 30 分钟膀胱中的放射性。这表明后者的尿排泄很快开始。另一方面，在给予载有 MMC 的微乳液后的 90 分钟内，膀胱中没有出现放射性。实验过程中肝脏中持续存在的放射性表明微乳液制剂在肝脏中的定位是稳定的。有鉴于此，建议这种微乳液制剂可能是通过肝内化疗静脉递送来递送抗癌药物的合适载体系统。
