从醉鱼草中分离出的两种新型胆碱酯酶抑制剂——醉鱼草酸酯A和B。
Two new cholinesterase inhibitors asiatoates A and B from Buddleja asiatica.
作者信息
Ali Farman, Khan Hidayat Ullah, Afzal Masood, Samad Abdul, Khan Shafi Ullah, Ali Irshad
机构信息
Department of Chemistry, Gomal University, Dera Ismail Khan, 27100, KPK, Pakistan.
出版信息
J Asian Nat Prod Res. 2013;15(6):631-7. doi: 10.1080/10286020.2013.794417. Epub 2013 May 10.
Two new benzoates, asiatoate A (1) and asiatoate B (2), have been isolated from the ethyl acetate soluble fraction of Buddleja asiatica whole plant. Their structures were elucidated with the help of spectroscopic data. Both showed significant inhibitory effect on acetylcholinesterase (AChE) and butylcholinesterase (BChE) in a dose-dependent manner. The IC50 values of compounds 1-2 were 5.54 and 8.34 μM against AChE while 30.94 and 35.94 μM against BChE, respectively.
从亚洲醉鱼草全株的乙酸乙酯可溶部分中分离出两种新的苯甲酸盐，即亚洲醉鱼草酸A（1）和亚洲醉鱼草酸B（2）。借助光谱数据阐明了它们的结构。两者均对乙酰胆碱酯酶（AChE）和丁酰胆碱酯酶（BChE）表现出显著的剂量依赖性抑制作用。化合物1-2对AChE的IC50值分别为5.54和8.34μM，对BChE的IC50值分别为30.94和35.94μM。
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