从盈江吴茱萸的叶子中分离得到的新呋喃喹啉生物碱。

New furoquinoline alkaloids from the leaves of Evodia lepta.

机构信息

Natural Products Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.

Walai Rukhavej Botanical Research Institute, Mahasarakham University, Mahasarakham 44000, Thailand.

出版信息

Fitoterapia. 2014 Jan;92:270-3. doi: 10.1016/j.fitote.2013.12.002. Epub 2013 Dec 9.

DOI:10.1016/j.fitote.2013.12.002

PMID:24333260

Abstract

Three new furoquinoline alkaloids, leptanoines A-C (1-3) along with three known compounds (4-6) were isolated from the leaves of Evodia lepta. Their structures were identified by interpretation of their spectroscopic data as well as comparison with those reported in the literature. In addition, all isolated compounds were evaluated for their acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities. Compound 4 showed the highest inhibitory activity towards BChE with an IC50 value of 47.9 μM. On the other hand, Compound 5 showed the highest inhibitory activity towards AChE with an IC50 value of 69.1 μM.

摘要

从黄皮树的叶子中分离得到了三个新的呋喃喹啉生物碱，即 leptanoines A-C（1-3），以及三个已知化合物（4-6）。通过对其光谱数据的解释以及与文献报道的化合物的比较，确定了它们的结构。此外，还评估了所有分离得到的化合物对乙酰胆碱酯酶（AChE）和丁酰胆碱酯酶（BChE）的活性。化合物 4 对 BChE 的抑制活性最高，IC50 值为 47.9 μM。另一方面，化合物 5 对 AChE 的抑制活性最高，IC50 值为 69.1 μM。