乳腺癌的妊娠保护：新见解揭示了未解决的问题。
Pregnancy protection of breast cancer: new insights reveal unanswered questions.
作者信息
Medina Daniel
出版信息
Breast Cancer Res. 2013 May 8;15(3):103. doi: 10.1186/bcr3414.
Abstract
The recent paper by Meier-Abt and colleagues on pregnancy protection of breast cancer development takes a different approach to the problem and focused on the effect of parity on the cell subpopulations of the mouse mammary gland. Their results demonstrate that parity decreases the cell number of the hormone receptor-positive luminal cells (that is, luminal Sca1+) but not the basal stem/progenitor cells (CD24lo/CD49hi). Additionally, microarray studies demonstrate that wnt4 expression from the luminal Sca1+ cells is markedly reduced as is the wnt signaling pathway in basal cells. One important implication from these results is that targeting the wnt signaling pathway might be a feasible prevention approach in humans.
摘要
迈尔 - 阿特及其同事近期发表的关于乳腺癌发展的妊娠保护作用的论文，对该问题采用了不同的研究方法，重点关注胎次对小鼠乳腺细胞亚群的影响。他们的研究结果表明，胎次会减少激素受体阳性的管腔细胞（即管腔Sca1 +细胞）的数量，但不会减少基底干细胞/祖细胞（CD24lo/CD49hi）的数量。此外，微阵列研究表明，管腔Sca1 +细胞中的wnt4表达显著降低，基底细胞中的wnt信号通路也是如此。这些结果的一个重要启示是，针对wnt信号通路可能是人类可行的预防方法。
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本文引用的文献
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