Department of Health and Sports Sciences, Tokyo Gakugei University, 4-1-1 Nukuikitamachi, Koganei 184-8501, Japan.
Nutr Metab (Lond). 2013 May 9;10(1):38. doi: 10.1186/1743-7075-10-38.
Both exercise and vitamin E supplementation have been shown to reduce oxidative stress and cardiovascular disease risk in older adults, and when combined there is evidence suggesting that they act synergistically. The currently recommended amount of exercise for older adults is 150 min/week of moderate-intensity exercise; however, the minimum amount of exercise necessary to achieve health benefits is not known. The purpose of this study was to investigate the effects of 12 weeks of participation in a low-volume walking exercise programme (i.e. 90 min/week) combined with daily vitamin E supplementation on thiobarbituric acid reactive substances (TBARS) and oxidised low-density lipoprotein (LDL) concentrations in older adults.
The participants were recruited from the following four groups separately: 1) control (CG, n = 14), 2) vitamin E supplementation (SG, n = 10), 3) walking (WG, n = 7), or 4) walking + supplementation (WSG, n = 7). In the CG, participants were advised to maintain their normal lifestyle during the study. Participants in both the SG and WSG received 450 IU (300 mg) /day of α-tocopherol for 12 weeks. The exercise programme for the WG and WSG consisted of two 30-60 minute sessions weekly for 12 weeks (average walking time was 44.5 ± 1.6 min/session). Blood samples were collected at baseline and at 12 weeks.
Delta plasma oxidised LDL concentrations did not differ among four groups (One-factor ANOVA, P = 0.116). However, negative delta plasma TBARS, a marker of oxidative damage, concentrations were observed in the WG, WSG and SG relative to the CG at the end of the study period (One-factor ANOVA, P = 0.001; post hoc tests; CG compared with WG, WSG and SG, P = 0.005; P = 0.021; P = 0.024, respectively).
These findings suggest that a low-volume of physical activity and/or vitamin E supplementation may be an effective intervention strategy for reducing TBARS concentrations of older adults.
UMIN000008304.
运动和维生素 E 补充都已被证明可以降低老年人的氧化应激和心血管疾病风险，并且当两者结合时，有证据表明它们具有协同作用。目前建议老年人每周进行 150 分钟的中等强度运动；然而，达到健康益处所需的最低运动量尚不清楚。本研究的目的是调查参加低容量步行运动计划（即每周 90 分钟）和每天补充维生素 E 对老年人硫代巴比妥酸反应物质（TBARS）和氧化低密度脂蛋白（LDL）浓度的影响，共持续 12 周。
参与者分别从以下四个组中招募：1）对照组（CG，n=14）、2）维生素 E 补充组（SG，n=10）、3）步行组（WG，n=7）或 4）步行+补充组（WSG，n=7）。在 CG 中，参与者被建议在研究期间保持正常的生活方式。SG 和 WSG 组的参与者每天服用 450 IU（300mg）α-生育酚 12 周。WG 和 WSG 的运动方案是每周进行两次 30-60 分钟的运动，共 12 周（平均步行时间为 44.5±1.6 分钟/次）。在基线和 12 周时采集血液样本。
四组间血浆氧化 LDL 浓度的变化无差异（单因素方差分析，P=0.116）。然而，在研究结束时，与 CG 相比，WG、WSG 和 SG 中血浆 TBARS 的变化呈负相关，TBARS 是氧化损伤的标志物（单因素方差分析，P=0.001；事后检验；CG 与 WG、WSG 和 SG 相比，P=0.005；P=0.021；P=0.024）。
这些发现表明，低容量的身体活动和/或维生素 E 补充可能是降低老年人 TBARS 浓度的有效干预策略。
UMIN000008304。
Zotero 插件
