Laboratory of Psychoneuroimmunology, Nutrition and Genetics (PSYNUGEN), INRA 1286 - University Victor Segalen Bordeaux 2, CNRS 5226, 146 rue Léo Saignat, Bordeaux F-33076, France.
Br J Nutr. 2009 Nov;102(10):1390-4. doi: 10.1017/S0007114509990493.
Chronic low-grade inflammation is a characteristic of ageing that may lead to alterations in health status and quality of life. In addition to intrinsic biological factors, recent data suggest that poor nutritional habits may largely contribute to this condition. The present study aimed at assessing mental and physical components of quality of life and at determining their relationship to vitamin E status, inflammation and tryptophan (TRP) metabolism in the elderly. Sixty-nine elderly subjects recruited from the Three-City cohort study participated in the study. Quality of life was assessed using the medical outcomes study thirty-six-item short-form health survey (SF-36). Biological assays included the measurement of plasma vitamin E (alpha-tocopherol), inflammatory markers, including IL-6 and C-reactive protein, and TRP metabolism. Results showed that participants with poor physical health status, as assessed by the SF-36, exhibited lower circulating concentrations of alpha-tocopherol together with increased concentrations of inflammatory markers. Similarly, poor mental health scores on the SF-36 were associated with lower concentrations of alpha-tocopherol, but also with decreased concentrations of TRP. These findings indicate that nutritional status, notably as it relates to vitamin E, is associated with immune function and quality of life in the elderly.
慢性低度炎症是衰老的一个特征，可能导致健康状况和生活质量的改变。除了内在的生物因素外，最近的数据表明，不良的营养习惯可能在很大程度上导致这种情况。本研究旨在评估老年人的生活质量的心理和生理成分，并确定它们与维生素 E 状态、炎症和色氨酸（TRP）代谢之间的关系。从三城市队列研究中招募了 69 名老年人参加了这项研究。使用医疗结果研究 36 项简短健康调查（SF-36）来评估生活质量。生物检测包括测量血浆维生素 E（α-生育酚）、炎症标志物，包括 IL-6 和 C-反应蛋白，以及 TRP 代谢。结果表明，SF-36 评估的身体健康状况较差的参与者，其循环中的α-生育酚浓度较低，同时炎症标志物浓度增加。同样，SF-36 上的心理健康评分较差与较低的α-生育酚浓度有关，但也与 TRP 浓度降低有关。这些发现表明，营养状况，特别是与维生素 E 有关的营养状况，与老年人的免疫功能和生活质量有关。
