Møller S, Iversen P
Ugeskr Laeger. 1989 Jan 16;151(3):173-4.
A case of severe toxic hepatitis in a patient with metastatic prostatic cancer treated for three months with flutamide (Eulexin) combined with an LHRH analogue, goserelin (Zoladex) is described. The patient developed severe liver failure with jaundice, ascites and severe encephalopathy. The condition reversed after discontinuation of flutamide. Less severe, but otherwise similar, adverse reactions have been reported in the literature, and the importance of considering the drug as a potential hepatotoxin is stressed.
本文描述了一名转移性前列腺癌患者，使用氟他胺（福至尔）联合促性腺激素释放激素类似物戈舍瑞林（诺雷德）治疗三个月后发生严重中毒性肝炎的病例。该患者出现了伴有黄疸、腹水和严重脑病的严重肝衰竭。停用氟他胺后病情好转。文献中报道过不太严重但类似的不良反应，并强调了将该药物视为潜在肝毒素的重要性。
