Lowy Cancer Research Centre and Prince of Wales Clinical School, University of New South Wales, Sydney NSW 2052, Australia.
Nat Rev Cancer. 2013 Jun;13(6):425-31. doi: 10.1038/nrc3519. Epub 2013 May 10.
Protein action in nature is generally controlled by the amount of protein produced and by chemical modification of the protein, and both are often perturbed in cancer. The amino acid side chains and the peptide and disulphide bonds that bind the polypeptide backbone can be post-translationally modified. Post-translational cleavage or the formation of disulphide bonds are now being identified in cancer-related proteins and it is timely to consider how these allosteric bonds could be targeted for new therapies.
蛋白质在自然界中的作用通常受到蛋白质产生量和蛋白质化学修饰的控制，而这两者在癌症中通常都会受到干扰。氨基酸侧链以及连接多肽主链的肽键和二硫键可以进行翻译后修饰。在癌症相关蛋白中，现在正在鉴定翻译后切割或二硫键的形成，现在正是考虑如何针对这些变构键开发新疗法的时机。
