Yonas H, Gur D, Claassen D, Wolfson S K, Moossy J
Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pennsylvania.
J Neurosurg. 1990 Aug;73(2):266-73. doi: 10.3171/jns.1990.73.2.0266.
When the lateral striate arteries of the baboon are temporarily occluded for either 20 or 60 minutes, a near-cessation of blood flow is followed by a dramatic, transient local increase in blood flow values. These findings are evident from serial xenon (Xe)-computerized tomography (CT) measurement of cerebral blood flow (CBF). In this study, 20 minutes of vessel occlusion resulted in brief (less than 1 hour) hyperemia, with no subsequent CT alteration and minimal random neuronal injury. Sixty minutes of occlusion resulted in a more prolonged hyperemia, a low-density area on CT images within 3 hours of reperfusion, and infarction of all cellular elements within the anterior lentiform nucleus. The Xe-CT method provides a sensitive, noninvasive technique for examining sequential alterations of CBF in small regions deep within the brain. This method of recording CBF also permits correlative studies of cerebral infarction, both clinically and experimentally, and allows reasonable inference about the probabilities of neuronal tissue damage with or without reperfusion.
当狒狒的外侧纹状动脉暂时闭塞20分钟或60分钟时，血流近乎停止后会出现血流量值急剧、短暂的局部增加。这些发现通过连续氙（Xe）-计算机断层扫描（CT）测量脑血流量（CBF）得以明确。在本研究中，血管闭塞20分钟导致短暂（少于1小时）的充血，随后CT无改变，随机神经元损伤极小。闭塞60分钟导致充血持续时间更长，再灌注后3小时内CT图像上出现低密度区，以及前豆状核内所有细胞成分梗死。Xe-CT方法为检查脑深部小区域CBF的连续变化提供了一种灵敏的非侵入性技术。这种记录CBF的方法还允许在临床和实验上对脑梗死进行相关性研究，并能合理推断有无再灌注时神经元组织损伤的可能性。
