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SRSF2 mutation is present in the hypercellular and prefibrotic stage of primary myelofibrosis.

作者信息

Lehmann Ulrich, Bartels Stephan, Hasemeier Britta, Geffers Robert, Schlue Jerome, Büsche Guntram, Hussein Kais, Kreipe Hans

出版信息

Blood. 2013 May 9;121(19):4011-2. doi: 10.1182/blood-2012-11-467662.

DOI:10.1182/blood-2012-11-467662
PMID:23660863
Abstract
摘要

相似文献

1
SRSF2 mutation is present in the hypercellular and prefibrotic stage of primary myelofibrosis.
Blood. 2013 May 9;121(19):4011-2. doi: 10.1182/blood-2012-11-467662.
2
SRSF2 and U2AF1 mutations in primary myelofibrosis are associated with JAK2 and MPL but not calreticulin mutation and may independently reoccur after allogeneic stem cell transplantation.原发性骨髓纤维化中的SRSF2和U2AF1突变与JAK2和MPL相关，但与钙网蛋白突变无关，且在异基因干细胞移植后可能独立复发。
Leukemia. 2015 Jan;29(1):253-5. doi: 10.1038/leu.2014.277. Epub 2014 Sep 18.
3
SRSF2 mutations in primary myelofibrosis: significant clustering with IDH mutations and independent association with inferior overall and leukemia-free survival.原发性骨髓纤维化中 SRSF2 突变：与 IDH 突变显著聚集，与总生存和无白血病生存不良独立相关。
Blood. 2012 Nov 15;120(20):4168-71. doi: 10.1182/blood-2012-05-429696. Epub 2012 Sep 11.
4
Mutations and prognosis in primary myelofibrosis.原发性骨髓纤维化中的突变与预后。
Leukemia. 2013 Sep;27(9):1861-9. doi: 10.1038/leu.2013.119. Epub 2013 Apr 26.
5
The detection of SRSF2 mutations in routinely processed bone marrow biopsies is useful in the diagnosis of chronic myelomonocytic leukemia.在常规处理的骨髓活检中检测SRSF2突变对慢性粒单核细胞白血病的诊断有用。
Hum Pathol. 2014 Dec;45(12):2471-9. doi: 10.1016/j.humpath.2014.08.014. Epub 2014 Sep 7.
6
Molecular correlates of anemia in primary myelofibrosis: a significant and independent association with U2AF1 mutations.原发性骨髓纤维化中贫血的分子关联：与U2AF1突变存在显著且独立的关联。
Blood Cancer J. 2016 Apr 8;6(4):e415. doi: 10.1038/bcj.2016.22.
7
U2AF1 mutations in primary myelofibrosis are strongly associated with anemia and thrombocytopenia despite clustering with JAK2V617F and normal karyotype.原发性骨髓纤维化中的U2AF1突变与贫血和血小板减少症密切相关，尽管其与JAK2V617F聚集且核型正常。
Leukemia. 2014 Feb;28(2):431-3. doi: 10.1038/leu.2013.286. Epub 2013 Oct 7.
8
Screening for ASXL1 and SRSF2 mutations is imperative for treatment decision-making in otherwise low or intermediate-1 risk patients with myelofibrosis.对于骨髓纤维化风险为低或中-1级的患者，检测ASXL1和SRSF2突变对于治疗决策至关重要。
Br J Haematol. 2018 Nov;183(4):678-681. doi: 10.1111/bjh.15010. Epub 2017 Nov 23.
9
[SRSF2 mutation in patients with chronic myelomonocytic leukemia].慢性粒单核细胞白血病患者中的SRSF2突变
Zhonghua Xue Ye Xue Za Zhi. 2013 Dec;34(12):1024-7. doi: 10.3760/cma.j.issn.0253-2727.2013.12.006.
10
Frequency and prognostic impact of mutations in SRSF2, U2AF1, and ZRSR2 in patients with myelodysplastic syndromes.骨髓增生异常综合征患者中 SRSF2、U2AF1 和 ZRSR2 突变的频率及其预后影响。
Blood. 2012 Apr 12;119(15):3578-84. doi: 10.1182/blood-2011-12-399337. Epub 2012 Mar 2.

引用本文的文献

1
Fibrotic progression in Polycythemia vera is associated with early concomitant driver-mutations besides JAK2.真性红细胞增多症中的纤维化进展除了与JAK2相关外，还与早期同时出现的驱动基因突变有关。
Leukemia. 2018 Feb;32(2):556-558. doi: 10.1038/leu.2017.298. Epub 2017 Sep 22.
2
Routine clinical mutation profiling using next generation sequencing and a customized gene panel improves diagnostic precision in myeloid neoplasms.使用下一代测序和定制基因检测板进行常规临床突变分析可提高髓系肿瘤的诊断准确性。
Oncotarget. 2016 May 24;7(21):30084-93. doi: 10.18632/oncotarget.8310.
3
[Diagnostic molecular pathology of lymphatic and myeloid neoplasms].
[淋巴和髓系肿瘤的诊断分子病理学]
Pathologe. 2015 Mar;36(2):164-70. doi: 10.1007/s00292-015-0007-1.
4
SRSF2 and U2AF1 mutations in primary myelofibrosis are associated with JAK2 and MPL but not calreticulin mutation and may independently reoccur after allogeneic stem cell transplantation.原发性骨髓纤维化中的SRSF2和U2AF1突变与JAK2和MPL相关，但与钙网蛋白突变无关，且在异基因干细胞移植后可能独立复发。
Leukemia. 2015 Jan;29(1):253-5. doi: 10.1038/leu.2014.277. Epub 2014 Sep 18.