Department of Dermatology and Pediatric Dermatology, National Centre for Rare Skin Disorders, Pellegrin Children's Hospital, Bordeaux, France.
Br J Dermatol. 2013 Dec;169(6):1252-6. doi: 10.1111/bjd.12432.
Although propranolol has become the first-line therapy for infantile haemangiomas (IHs), no study has yet investigated factors associated with the risk of relapse in children with IH treated with propranolol after cessation of treatment.
To compare factors associated with the risk of relapse in children with IH treated with oral propranolol.
We conducted a single-centre retrospective observational study. All files and photographs of patients with IH aged 5 months or less at the time of treatment initiation, and who were seen between 1 June 2008 and 31 December 2011 at the National Reference Center for rare skin diseases of Bordeaux, were retrospectively reviewed.
In total 158 children were included, of whom 118 had not relapsed and 40 had relapsed. Fifty-two patients were boys and 106 were girls (male : female ratio 1 : 2), and 19 had a segmental IH (12%). When conducting multivariate analysis, only IHs with a deep component and those with segmental distribution were independently associated with relapse.
Our study shows that segmental IHs, as well as haemangiomas with a deeper component, are more at risk of relapse and should thus indicate closer follow-up after treatment interruption, and/or longer treatment.
尽管普萘洛尔已成为婴幼儿血管瘤（IH）的一线治疗药物，但尚无研究调查治疗停止后接受普萘洛尔治疗的 IH 患儿复发风险的相关因素。
比较口服普萘洛尔治疗的 IH 患儿复发风险的相关因素。
我们进行了一项单中心回顾性观察性研究。所有在 2008 年 6 月 1 日至 2011 年 12 月 31 日期间在波尔多国家罕见皮肤病参考中心就诊的，治疗开始时年龄在 5 个月或以下的 IH 患儿的所有病历和照片均进行了回顾性审查。
共纳入 158 例患儿，其中 118 例未复发，40 例复发。52 例患儿为男性，106 例为女性（男：女比例为 1：2），19 例为节段性 IH（12%）。进行多变量分析时，仅具有深部成分的 IH 和具有节段性分布的 IH 与复发独立相关。
本研究表明，节段性 IH 以及具有深部成分的 IH 复发风险更高，因此在治疗中断后应进行更密切的随访，和/或延长治疗。
