Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of Alberta, 8440 112 Street NW, Edmonton, Alberta, T6G 2P4, Canada.
J Otolaryngol Head Neck Surg. 2013 Jan 31;42(1):2. doi: 10.1186/1916-0216-42-2.
Sinonasal undifferentiated carcinoma (SNUC) is a rare malignancy with often dismal outcomes. This study set to determine provincial and literature-wide survival outcomes based on treatment modality.
Retrospective chart review of all SNUC patients in the province of Alberta from 1986-2010 was conducted. A review of the literature of SNUC patients was also performed. Patient/tumor characteristics, treatment, and follow-up/survival data were collected. Kaplan-Meier and Cox regression survival analyses were performed.
20 patients were treated for SNUC in Alberta and 140 patients were identified in the literature. Pooled median disease-free survival was 12. 7 months and 5-year survival estimate was 6.25%. Cox-Regression analysis demonstrated an overall survival advantage with multimodality treatments (Log-Rank test: p = 0.015). However, no statistically significant differences in disease-free and overall survival were identified between patients treated with chemoradiation or surgery followed by adjuvant therapy.
Treatment of SNUC remains challenging with poor survival outcomes. There appears to be no statistically significant difference in overall, or disease-free survival between treatment modalities.
鼻腔鼻窦未分化癌（SNUC）是一种罕见的恶性肿瘤，通常预后较差。本研究旨在根据治疗方式确定省级和文献范围内的生存结果。
对 1986 年至 2010 年艾伯塔省所有 SNUC 患者进行回顾性图表审查。还对 SNUC 患者的文献进行了回顾。收集了患者/肿瘤特征、治疗和随访/生存数据。进行了 Kaplan-Meier 和 Cox 回归生存分析。
在艾伯塔省治疗了 20 例 SNUC 患者，在文献中鉴定了 140 例患者。汇总的中位无疾病生存率为 12.7 个月，5 年生存率估计值为 6.25%。Cox 回归分析表明，采用多模式治疗具有总体生存优势（对数秩检验：p=0.015）。然而，接受放化疗或手术加辅助治疗的患者之间，无疾病和总体生存率无统计学显著差异。
SNUC 的治疗仍然具有挑战性，生存结果不佳。治疗方式之间的总生存率或无病生存率似乎没有统计学显著差异。
