Department of Neurosurgery, Hadassah-Hebrew University Medical Center, P.O. Box 12000, Jerusalem 91120, Israel.
J Clin Neurosci. 2013 Jul;20(7):1032-4. doi: 10.1016/j.jocn.2012.07.022. Epub 2013 May 9.
Superficial siderosis of the central nervous system (CNS) is a rare disorder caused by deposition of hemosiderin in neuronal tissue in the subpial layer of the CNS due to slow subarachnoid or intraventricular hemorrhage. The most common neurologic manifestations include progressive gait ataxia, sensorineural hearing loss, and corticospinal tract signs. We present a case of superficial siderosis in a 43-year-old man who presented to the Emergency Department with sudden onset bilateral visual deterioration and a loss of consciousness. A hemorrhagic giant prolactinoma was diagnosed based on brain CT scan, T1-weighted MRI, and an endocrine blood examination. Susceptibility-weighted non-contrast MRI showed pathognomonic signs of superficial siderosis in the form of a hypointensity rim surrounding the brainstem, cerebellar fissures, and cranial nerves VII and VIII. This report demonstrates that superficial siderosis can be caused by pituitary apoplexy.
中枢神经系统（CNS）表面铁沉积症是一种罕见疾病，由于蛛网膜下腔或脑室缓慢出血，导致 CNS 软脑膜下层的神经元组织中铁红素沉积。最常见的神经表现包括进行性步态共济失调、感觉神经性听力损失和皮质脊髓束征。我们报告了一例 43 岁男性病例，该患者因突然出现双侧视力恶化和意识丧失而到急诊科就诊。根据脑 CT 扫描、T1 加权 MRI 和内分泌血液检查，诊断为出血性巨大泌乳素瘤。磁敏感加权非对比 MRI 显示了以脑干、小脑裂和颅神经 VII 和 VIII 为边界的低信号环为特征的表面铁沉积症的典型征象。本报告表明，垂体卒中可引起表面铁沉积症。
