Sakaida Hiroshi, Masuda Sawako, Takeuchi Kazuhiko
Department of Otorhinolaryngology, Head & Neck Surgery, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie 514-8507, Japan.
Auris Nasus Larynx. 2013 Dec;40(6):543-7. doi: 10.1016/j.anl.2013.04.001. Epub 2013 May 8.
Japanese cedar pollinosis is increasing rapidly in Japan. Although analysis has been made concerning the factors influencing the development of the cedar pollinosis, analysis concerning the risk factors influencing the sensitization in asymptomatic subjects has not been done.
Risk factors for sensitization to Japanese cedar pollen were analyzed among 73 subjects (32 men and 41 women) who do not develop symptoms of pollinosis at the time of Japanese cedar pollen scattering. Their ages ranged from 18 to 60 years with the mean of 34.1 years. Possible factors influencing sensitization were investigated through a written questionnaire and doctors' questioning. Japanese cedar-specific IgE titers and Dermatophagoides pteronyssinus-specific IgE titers in the serum were measured by CAP-FEIA (fluorescent enzyme immunoassay).
Of the 73 subjects, 26 were sensitized to the Japanese cedar pollen, for a 36% sensitization rate. Among the eleven factors examined, only one factor was shown to significantly influence the sensitization rate to Japanese cedar pollen. It was sensitization to house dust mites (56.5% vs. 26.0% χ(2) value=6.27, p=0.012). The sensitization rate to the pollen did not correlate to the presence of other allergic diseases, history of rhinosinusitis, family history of Japanese cedar pollinosis, food preference, presence or absence of cedar trees in the surroundings, present living circumstances, childhood circumstances, age, sex, or smoking habits. We calculated odds ratios in order to estimate how much those factors influence the sensitization to Japanese cedar pollen. Significantly high odds ratio for sensitization to house dust mite (6.63; 95% confidence interval (CI): 1.76-32.2) was found.
The present study indicates that sensitization to the pollen in the subjects without pollinosis is influenced by sensitization to house dust mite.
日本雪松花粉症在日本正迅速增加。虽然已对影响雪松花粉症发展的因素进行了分析，但尚未对影响无症状受试者致敏的危险因素进行分析。
对73名在日本雪松花粉飘散时未出现花粉症症状的受试者（32名男性和41名女性）进行了雪松花粉致敏危险因素分析。他们的年龄在18至60岁之间，平均年龄为34.1岁。通过书面问卷和医生询问调查了可能影响致敏的因素。采用CAP-FEIA（荧光酶免疫测定法）测定血清中日本雪松特异性IgE滴度和粉尘螨特异性IgE滴度。
73名受试者中，26名对日本雪松花粉致敏，致敏率为36%。在所检查的11个因素中，只有一个因素被证明对日本雪松花粉致敏率有显著影响。即对屋尘螨致敏（56.5%对26.0%，χ(2)值 = 6.27，p = 0.012）。对花粉的致敏率与其他过敏性疾病的存在、鼻窦炎病史、日本雪松花粉症家族史、食物偏好、周围环境中是否有雪松、当前生活环境、童年环境、年龄、性别或吸烟习惯无关。我们计算了优势比，以估计这些因素对日本雪松花粉致敏的影响程度。发现对屋尘螨致敏的优势比显著较高（6.63；95%置信区间（CI）：1.76 - 32.2）。
本研究表明，无花粉症受试者对花粉的致敏受对屋尘螨致敏的影响。
