Department of Otorhinolaryngology, Head & Neck Surgery, Mie University Graduate School of Medicine, Mie, Japan.
School of Medicine, Mie University, Mie, Japan.
Allergol Int. 2019 Jan;68(1):39-45. doi: 10.1016/j.alit.2018.05.006. Epub 2018 Jun 13.
Genetic and environmental factors are proposed to be involved in cedar pollen allergy sensitization and onset. The impact of these factors will provide key information for the prevention of cedar pollen sensitization and allergy onset, which we investigated in this cross-sectional study.
Subjects were 382 young adult volunteers who completed a self-administered questionnaire on self-reported subjective symptoms of pollinosis, physician-diagnosed pollinosis, and background factors. We also measured their serum IgE antibody titers specific for cedar, cypress, and mites. Factors associated with subjective symptoms, physician diagnosis, and the three specific antigens were determined using both univariate and multivariate analyses.
Sensitization to cedar, cypress, and mites, defined as specific IgE levels of class 1 or above, was found in 78.8%, 64.4%, and 56.0% of subjects, respectively. The prevalence of cedar pollinosis was 41.2% based on subjective symptoms and 22.2% based on physician diagnosis. Factors associated with increased cedar pollen sensitization were mite sensitization, comorbid allergic rhinitis, and family history of cedar pollinosis. Risk-reducing factors for cedar pollen sensitization were keeping a cat, number of common colds, and hours of sleep. Risk-increasing factors for both subjective pollinosis symptoms and physician-diagnosed pollinosis were comorbid allergic rhinitis and family history of cedar pollinosis.
Sensitization to cedar pollen in this population was extremely high. Both common and distinct factors were associated with sensitization to pollen and with the development of pollinosis. The distinct factors were associated with sensitization to cedar and cypress antigens.
遗传和环境因素被认为与雪松花粉过敏致敏和发病有关。这些因素的影响将为预防雪松花粉致敏和过敏发病提供关键信息，我们在这项横断面研究中对此进行了调查。
382 名年轻成年志愿者完成了一份自我报告的花粉症主观症状、医生诊断的花粉症和背景因素的自我管理问卷。我们还测量了他们针对雪松、柏树和螨虫的血清 IgE 抗体滴度。使用单变量和多变量分析确定与主观症状、医生诊断和三种特定抗原相关的因素。
分别有 78.8%、64.4%和 56.0%的受试者对雪松、柏树和螨虫过敏，定义为特异性 IgE 水平为 1 级或以上。根据主观症状和医生诊断，雪松花粉症的患病率分别为 41.2%和 22.2%。与雪松花粉致敏增加相关的因素是螨虫致敏、共患过敏性鼻炎和雪松花粉症家族史。降低雪松花粉致敏风险的因素是养猫、普通感冒次数和睡眠时间。增加主观花粉症症状和医生诊断花粉症的风险因素是共患过敏性鼻炎和雪松花粉症家族史。
该人群对雪松花粉的致敏率极高。常见和独特的因素都与花粉致敏和花粉病的发生有关。独特的因素与对雪松和柏树抗原的致敏有关。
