van der Zypen E, Fankhauser F
Anatomisches Institut und Augenklinik der Universität Bern.
Klin Monbl Augenheilkd. 1990 May;196(5):338-41. doi: 10.1055/s-2008-1046188.
Retinopexy may be produced by either of two mechanisms following transpupillary irradiation of the retina with the Nd:YAG laser. Which of these mechanisms is operative will depend on the degree of disruption produced within the elastic component of Bruch's membrane. Small defects in the elastic component of Bruch's membrane are soon completely bridged by regenerated retinal pigment epithelium (RPE) cells. However, there is a risk of subretinal neovascularization in such defects. Large defects in the elastic component of Bruch's membrane are not completely bridged by regenerating RPE cells before proliferating Müller cells invade this region and spread from it, mushroom-like, within the choroid. In this case subretinal neovascularization does not occur. In the former instance (small defects) retinopexy is achieved by a process of interdigitation between the microvilli of Müller and RPE cells; and in the latter (large defects) via a press-stud-like anchorage of Müller cells within the choroid. It has not yet been established whether these two retinopexy phenomena, observed after irradiation of rabbit retinas, occur in the same way in man.
用钕钇铝石榴石激光经瞳孔照射视网膜后，视网膜固定术可通过两种机制中的任何一种来实现。这两种机制中哪种起作用取决于布鲁赫膜弹性成分内产生的破坏程度。布鲁赫膜弹性成分中的小缺陷很快会被再生的视网膜色素上皮（RPE）细胞完全桥接。然而，在这种缺陷中存在视网膜下新生血管形成的风险。在增殖的米勒细胞侵入该区域并在脉络膜内呈蘑菇状扩散之前，布鲁赫膜弹性成分中的大缺陷不会被再生的RPE细胞完全桥接。在这种情况下不会发生视网膜下新生血管形成。在前一种情况（小缺陷）中，视网膜固定术是通过米勒细胞和RPE细胞微绒毛之间的指状交叉过程实现的；而在后一种情况（大缺陷）中，则是通过米勒细胞在脉络膜内类似按扣的固定方式实现的。在兔子视网膜照射后观察到的这两种视网膜固定现象在人类中是否以相同方式发生尚未确定。
