Hsu H T, Goodnight R, Ryan S J
Department of Ophthalmology, University of Southern California School of Medicine, Los Angeles.
Jpn J Ophthalmol. 1989;33(3):358-66.
Subretinal choroidal neovascularization has been identified in the pigmented rabbit in association with penetrating retinal injury. In this study, the subretinal new vessels were not contained within the fibrous scar, but were located posterior to it and impinged on the visual streak. Histology revealed subretinal neovascularization in the region of transition from normal to atrophic retina. These new vessels originated from the choroidal vessels and extended through a spontaneous break in Bruch's membrane into the retinal pigment epithelium. There was degeneration of the photoreceptors and hyperplasia of the retinal pigment epithelium in the region of neovascularization. The subretinal new vessels identified in the pigmented rabbit have many of the morphological features seen in the human clinical condition, and therefore this animal model may be useful in studying human choroidal neovascularization.
在有色素的兔子中，视网膜下脉络膜新生血管形成与穿透性视网膜损伤有关。在本研究中，视网膜下新生血管不在纤维瘢痕内，而是位于其后方并侵犯视条纹。组织学显示，在从正常视网膜向萎缩性视网膜转变的区域存在视网膜下新生血管形成。这些新生血管起源于脉络膜血管，并通过布鲁赫膜的自发性破裂延伸至视网膜色素上皮。在新生血管形成区域存在光感受器变性和视网膜色素上皮增生。在有色素的兔子中发现的视网膜下新生血管具有许多人类临床疾病中所见的形态学特征，因此该动物模型可能有助于研究人类脉络膜新生血管形成。
