Airway Disease Infection Section, National Heart Lung Institute, Imperial College London, UK.
Curr Opin Pharmacol. 2013 Jun;13(3):331-6. doi: 10.1016/j.coph.2013.04.010. Epub 2013 May 9.
Asthma is the most common chronic respiratory disease and its prevalence is on the increase. Respiratory viral infections in early life have been suggested to increase the risk of development of asthma in later life and virus infection remains the single greatest precipitant of asthma exacerbations. The development of effective anti-viral treatments remains a key target for therapeutic intervention. Here we discuss the role of respiratory viral infection in asthma exacerbation and highlight current and potential anti-viral agents and their mechanisms of action.
哮喘是最常见的慢性呼吸道疾病，其发病率呈上升趋势。有研究表明，生命早期的呼吸道病毒感染会增加日后发生哮喘的风险，病毒感染仍然是哮喘恶化的最大单一诱因。开发有效的抗病毒治疗方法仍然是治疗干预的一个关键目标。本文讨论了呼吸道病毒感染在哮喘恶化中的作用，并重点介绍了目前和潜在的抗病毒药物及其作用机制。
