National Heart and Lung Institute, Imperial College London, Norfolk Place, London, W2 1PG, UK; Department of Respiratory Medicine, St Mary's Hospital, Imperial College Healthcare NHS Trust, Praed Street, London, W2 1NY, UK.
National Heart and Lung Institute, Imperial College London, Norfolk Place, London, W2 1PG, UK; Department of Respiratory Medicine, Harefield Hospital, Royal Brompton & Harefield NHS Foundation Trust, Hill End Road, Harefield, UB9 6JH, UK.
Acta Med Acad. 2020 Aug;49(2):130-143. doi: 10.5644/ama2006-124.292.
In this review, we discuss the latest developments in research pertaining to virus-induced asthma exacerbations and consider recent advances in treatment options. Asthma is a chronic disease of the airways that continues to impose a substantial clinical burden worldwide. Asthma exacerbations, characterised by an acute deterioration in respiratory symptoms and airflow obstruction, are associated with significant morbidity and mortality. These episodes are most commonly triggered by respiratory virus infections. The mechanisms underlying the pathogenesis of virus-induced exacerbations have been the focus of extensive biomedical research. Developing a robust understanding of the interplay between respiratory viruses and the host immune response will be critical for developing more efficacious, targeted therapies for exacerbations. CONCLUSION: There has been significant recent progress in our understanding of the mechanisms underlying virus-induced airway inflammation in asthma and these advances will underpin the development of future clinical therapies.
在这篇综述中，我们讨论了与病毒引起的哮喘恶化相关的最新研究进展，并考虑了最近在治疗选择方面的进展。哮喘是一种气道的慢性疾病，在全球范围内仍造成了巨大的临床负担。哮喘恶化的特点是呼吸症状和气流阻塞的急性恶化，与显著的发病率和死亡率相关。这些发作最常见于呼吸道病毒感染。病毒引起的恶化发病机制一直是广泛的生物医学研究的重点。深入了解呼吸道病毒与宿主免疫反应之间的相互作用对于开发更有效的、针对恶化的靶向治疗方法至关重要。结论：我们对哮喘中病毒引起的气道炎症的机制有了显著的最新认识，这些进展将为未来的临床治疗方法的发展提供基础。
