Gustafsson L E, Persson M G, Ohlén A, Hedqvist P, Lindbom L
Department of Physiology, Karolinska Institute, Stockholm, Sweden.
Naunyn Schmiedebergs Arch Pharmacol. 1990 May;341(5):444-9. doi: 10.1007/BF00176338.
The effects of adenosine and adenosine antagonists on arteriolar vessel diameters were studied in the rabbit tenuissimus muscle in situ by means of intravital microscopy. Topically applied adenosine dose-dependently dilated transverse and terminal arterioles, an effect which was competitively antagonized by alkylxanthines. Topically applied alkylxanthines per se evoked dose-dependent vasoconstriction with the same potency order as for their adenosine antagonism. Furthermore, the concentrations of alkylxanthines eliciting vasoconstriction correlated with the observed pA2 values for their adenosine antagonism. The data indicate a physiological role of adenosine, or other purines, as regulator of resting vascular tone in mammalian skeletal muscle.
采用活体显微镜技术，在原位兔薄肌中研究了腺苷和腺苷拮抗剂对小动脉血管直径的影响。局部应用腺苷可使横向和终末小动脉呈剂量依赖性扩张，该效应可被烷基黄嘌呤竞争性拮抗。局部应用烷基黄嘌呤本身可引起剂量依赖性血管收缩，其效力顺序与其对腺苷的拮抗作用相同。此外，引起血管收缩的烷基黄嘌呤浓度与其腺苷拮抗作用的观察到的pA2值相关。这些数据表明腺苷或其他嘌呤在调节哺乳动物骨骼肌静息血管张力方面具有生理作用。
