Evi5 家族在细胞生理学和病理学中的作用。

The Evi5 family in cellular physiology and pathology.

机构信息

Department of Biochemistry, Yong Loo Lin School of Medicine, National University Health System, Singapore.

出版信息

FEBS Lett. 2013 Jun 19;587(12):1703-10. doi: 10.1016/j.febslet.2013.04.036. Epub 2013 May 10.

DOI:10.1016/j.febslet.2013.04.036

Abstract

The Ecotropic viral integration site 5 (Evi5) and Evi5-like (Evi5L) belong to a small subfamily of the Tre-2/Bub2/Cdc16 (TBC) domain-containing proteins with enigmatically divergent roles as modulators of cell cycle progression, cytokinesis, and cellular membrane traffic. First recognized as a potential oncogene and a cell cycle regulator, Evi5 acts as a GTPase Activating Protein (GAP) for Rab11 in cytokinesis. On the other hand, its homologue Evi5L has Rab-GAP activity towards Rab10 as well as Rab23, and has been implicated in primary cilia formation. Recent genetic susceptibility analysis points to Evi5 as an important factor in susceptibility to multiple sclerosis. We discuss below the myriad of cellular functions exhibited by the Evi5 family members, and their associations with disease conditions.

摘要

嗜同性病毒整合位点 5（Evi5）和 Evi5 样（Evi5L）属于 Tre-2/Bub2/Cdc16（TBC）结构域蛋白的一个小亚家族，它们具有作为细胞周期进程、胞质分裂和细胞膜运输调节剂的作用，这些作用神秘地不同。Evi5 最初被认为是一种潜在的癌基因和细胞周期调节剂，它在胞质分裂中作为 Rab11 的 GTP 酶激活蛋白（GAP）。另一方面，它的同源物 Evi5L 对 Rab10 和 Rab23 具有 Rab-GAP 活性，并与初级纤毛形成有关。最近的遗传易感性分析表明，Evi5 是多发性硬化易感性的一个重要因素。我们在下面讨论了 Evi5 家族成员表现出的多种细胞功能及其与疾病状况的关联。