Shi Meng-Ting, Zhang Ying, Zhou Gang-Qiao
Graduate School, Guangxi Medical University, Nanning 530021, China; National Center for Protein Sciences, the State Key Lab of Proteomics, Beijing Institute of Radiation Medicine, Beijing 100850, China.
National Center for Protein Sciences, the State Key Lab of Proteomics, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Yi Chuan. 2018 Jan 20;40(1):12-21. doi: 10.16288/j.yczz.17-343.
The Tre-2/Bub2/Cdc16 (TBC) domain is a conserved protein motif consisting of approximately 200 amino acids, and is present in many eukaryotic proteins. TBC domain-containing proteins (TBC proteins) function as GTPase activating proteins (GAPs) for the small GTPase Rab, which can promote the hydrolysis of Rab-GTP to Rab-GDP in regulation of specific intracellular trafficking pathways. Several TBC proteins play important roles in cellular functions in mammals, and defects of which are closely associated with numerous disease processes. In this review, we summarize the structures and functions of the mammalian TBC proteins and recent advances in understanding their critical roles in the development of human diseases. This review serves as a reference for further investigations on the functions of TBC proteins in disease pathogeneses.
Tre-2/Bub2/Cdc16（TBC）结构域是一种由约200个氨基酸组成的保守蛋白基序，存在于许多真核生物蛋白质中。含TBC结构域的蛋白质（TBC蛋白）作为小GTP酶Rab的GTP酶激活蛋白（GAP）发挥作用，在特定细胞内运输途径的调节中可促进Rab-GTP水解为Rab-GDP。几种TBC蛋白在哺乳动物的细胞功能中发挥重要作用，其缺陷与众多疾病进程密切相关。在本综述中，我们总结了哺乳动物TBC蛋白的结构和功能，以及在理解它们在人类疾病发展中的关键作用方面的最新进展。本综述为进一步研究TBC蛋白在疾病发病机制中的功能提供参考。
