内镜超声诊断免疫球蛋白轻链（AL）淀粉样变性（原发性淀粉样变性）中胰腺淀粉样沉积的首例报告。
A first report of endoscopic ultrasound for the diagnosis of pancreatic amyloid deposition in immunoglobulin light chain (AL) amyloidosis (primary amyloidosis).
作者信息
Krishna Somashekar G, Bhutani Manoop S, Mosher Charles H, Staerkel Gregg A, Weston Brian R
机构信息
Department of Gastroenterology, Hepatology and Nutrition, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030-4009, USA.
出版信息
JOP. 2013 May 10;14(3):283-5. doi: 10.6092/1590-8577/1505.
Abstract
CONTEXT
Pancreatic involvement in systemic light chain (AL)-amyloidosis is exceedingly rare. Prior reports of endoscopic ultrasound (EUS) for the diagnosis of amyloidosis are also limited.
CASE REPORT
We report the first description of EUS-guided fine needle aspiration (FNA) for the diagnosis of primary AL-amyloidosis involving the pancreas.
CONCLUSION
EUS-FNA can be effectively utilized for the characterization and cytologic diagnosis of pancreatic amyloidosis and potentially other accessible extraluminal amyloid deposits.
摘要
背景
胰腺受累于系统性轻链（AL）淀粉样变极为罕见。既往关于内镜超声（EUS）用于诊断淀粉样变的报道也很有限。
病例报告
我们报告了首例关于EUS引导下细针穿刺抽吸（FNA）用于诊断累及胰腺的原发性AL淀粉样变的描述。
结论
EUS-FNA可有效用于胰腺淀粉样变以及潜在的其他可及的腔外淀粉样沉积物的特征描述和细胞学诊断。
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本文引用的文献
1
Endoscopic features of primary amyloidosis of the stomach.
Endoscopy. 2012;44 Suppl 2 UCTN:E275-6. doi: 10.1055/s-0032-1309750. Epub 2012 Jul 13.
2
Pancreatic islet cell amyloidosis manifesting as a large pancreas.胰腺胰岛细胞淀粉样变表现为巨胰。
Korean J Radiol. 2012 Jan-Feb;13(1):94-7. doi: 10.3348/kjr.2012.13.1.94. Epub 2011 Dec 23.
3
Primary gastroduodenal amyloidosis.原发性胃十二指肠淀粉样变性
Endoscopy. 2011;43 Suppl 2 UCTN:E288. doi: 10.1055/s-0030-1256420. Epub 2011 Sep 13.
4
Amyloidosis: an EUS view.
Gastrointest Endosc. 2012 Jan;75(1):218-20. doi: 10.1016/j.gie.2011.01.039. Epub 2011 Apr 5.
5
Gastrointestinal manifestations of amyloidosis.淀粉样变性的胃肠道表现。
Am J Gastroenterol. 2008 Mar;103(3):776-87. doi: 10.1111/j.1572-0241.2007.01669.x. Epub 2007 Dec 12.
6
Amyloid tumor: a clinical and cytomorphologic study.
Diagn Cytopathol. 2003 Jun;28(6):325-8. doi: 10.1002/dc.10296.
7
Amyloid in cytologic specimens. Differential diagnosis and diagnostic pitfalls.细胞标本中的淀粉样蛋白。鉴别诊断及诊断陷阱。
Acta Cytol. 1999 Sep-Oct;43(5):746-55. doi: 10.1159/000331286.
8
Fine-needle aspiration cytology of amyloid associated with nonneoplastic and malignant lesions.与非肿瘤性和恶性病变相关的淀粉样变的细针穿刺细胞学检查
Diagn Cytopathol. 1998 Apr;18(4):270-5. doi: 10.1002/(sici)1097-0339(199804)18:4<270::aid-dc4>3.0.co;2-g.
9
Primary systemic amyloidosis: clinical and laboratory features in 474 cases.原发性系统性淀粉样变性：474例患者的临床及实验室特征
Semin Hematol. 1995 Jan;32(1):45-59.
10
Endoscopic ultrasonography in the diagnosis of gastrointestinal amyloid deposits: clinical case report.内镜超声检查在胃肠道淀粉样沉积诊断中的应用：临床病例报告
Endoscopy. 1995 Jan;27(1):132-4. doi: 10.1055/s-2007-1005648.
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