Center for Regenerative Therapies Dresden and Biotechnology Center, Technische Universität Dresden, Fetscherstraße 105, 01307 Dresden, Germany.
Curr Opin Genet Dev. 2013 Aug;23(4):415-22. doi: 10.1016/j.gde.2013.03.002. Epub 2013 May 10.
Signalling via fibroblast growth factors (FGFs) is involved in multiple aspects of vertebrate development. In several instances FGFs act as morphogens, that is secreted signalling molecules that encode positional information in their graded distribution throughout their target tissue. In recent years, work in the zebrafish model system has been instrumental in addressing the cell biological basis of FGF morphogen gradient formation and interpretation. These experiments have benefitted from the optical properties of the zebrafish embryo that render this vertebrate organism particularly suited for advanced microscopic and biophysical approaches.
成纤维细胞生长因子 (FGFs) 的信号转导参与了脊椎动物发育的多个方面。在某些情况下，FGFs 作为形态发生素发挥作用，即分泌的信号分子，其在靶组织中的梯度分布中编码位置信息。近年来，斑马鱼模型系统的工作在解决 FGF 形态发生素梯度形成和解释的细胞生物学基础方面发挥了重要作用。这些实验受益于斑马鱼胚胎的光学特性，使这种脊椎动物特别适合先进的显微镜和生物物理方法。
