十一酸睾酮对去势兔血液学指标、血脂、血液黏度及血浆睾酮水平的影响。
Effect of testosterone undecanoate on hematological profiles, blood lipid and viscosity and plasma testosterone level in castrated rabbits.
作者信息
Zhao Chen, Moon Du Geon, Park Jong Kwan
机构信息
Department of Urology, Chonbuk National University Medical School, and Institute for Medical Sciences, Chonbuk National University, and Research Institute and CTC for Medical Device of Chonbuk National University Hospital, Jeonju; ; Department of Urology, Shanghai Institute of Andrology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;
出版信息
Can Urol Assoc J. 2013 Mar-Apr;7(3-4):E221-5. doi: 10.5489/cuaj.507.
OBJECTIVE
The association between testosterone replacement therapy and cardiovascular risk remains controversial. Blood viscosity is a known individual risk factor for cardiovascular disease mortality. The objective of the present study was to investigate the effects of the long-acting injectable testosterone undecanoate (TU) on risk factors of cardiovascular disease.
METHODS
In total, 24 male New Zealand white rabbits (2.5 kg) were randomly divided into 3 groups of 8. Group 1 was used as control. Group 2 was castrated bilaterally and Group 3 was administrated with 6 mg/kg of TU at day 1 and 6 weeks after castration. Whole blood viscosity, total plasma testosterone, hemoglobin (Hb), hematocrit (Hct), fibrinogen (FBN), total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) levels were measured at baseline, 6 weeks and 18 weeks.
RESULTS
In the control group, whole blood viscosity and FBN were significantly increased at 6 and 18 weeks. Castration significantly increased the levels of TC, TG, HDL-C and LDL-C, but decreased Hct and Hb. In the TU injection group, whole blood viscosity was markedly decreased in all share rates, whereas the FBN level was increased. Hb and Hct showed a tendency for higher concentration at 6 weeks.
CONCLUSIONS
Long-acting injectable TU provides another reliable treatment option for testosterone replacement therapy. Moreover, the patients may receive additional beneficial effect in lowered whole blood viscosity.
目的
睾酮替代疗法与心血管风险之间的关联仍存在争议。血液粘度是已知的心血管疾病死亡率的个体风险因素。本研究的目的是调查长效注射用十一酸睾酮（TU）对心血管疾病风险因素的影响。
方法
总共24只雄性新西兰白兔（2.5千克）被随机分为3组，每组8只。第1组用作对照。第2组进行双侧去势，第3组在去势后第1天和第6周给予6毫克/千克的TU。在基线、6周和18周时测量全血粘度、总血浆睾酮、血红蛋白（Hb）、血细胞比容（Hct）、纤维蛋白原（FBN）、总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C）水平。
结果
在对照组中，全血粘度和FBN在6周和18周时显著增加。去势显著增加了TC、TG、HDL-C和LDL-C的水平，但降低了Hct和Hb。在TU注射组中，所有切变率下全血粘度均显著降低，而FBN水平升高。Hb和Hct在6周时呈现浓度升高的趋势。
结论
长效注射用TU为睾酮替代疗法提供了另一种可靠的治疗选择。此外，患者在降低全血粘度方面可能会获得额外的益处。
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