Adedapo A D A, Sikuade O, Adeleke S, Okechukwu R
Department of Pharmacology and Therapeutics, University of Ibadan, Ibadan, Nigeria.
Afr J Med Med Sci. 2012 Dec;41(4):349-56.
To assess the current utilization pattern of antihypertensive drugs and blood pressure (BP) control among treated hypertensives where there is a change in payment policy for antihypertensive drugs and to compare with a previous study when drugs were given free in the same setting.
A cross sectional study of hypertensive subjects being followed-up in the medical clinic of International Institute for Tropical Agriculture.
One hundred and sixteen consecutive hypertensive subjects aged 50.9+/-8.6 years were studied. Eighty two (70.7%) of the subjects were fully controlled on the treatment, while 15 (12.9%) were not controlled at all. Systolic BP alone was controlled in 14 (12.1%) while in 5 (4.3%) subjects the Diastolic BP alone was controlled. Systolic BP was 133.4+/-14.0 (106-186) mmHg, while diastolic was 83.5+/-9.1 (59-110) mmHg. Salt use correlated with and was predictive of BP control, r = 0.336 and r2 = 3.383, p=0.001. Frequency of drug use: Diuretics 79.8%, calcium channel blockers (CCB) 51.8%, alpha-methyldopa 21.9%, angiotensin converting enzyme inhibitors 17.5%, beta-blockers 15.8%, vasodilator 1.8%, and prazosin 0.9%.
In this study, twice as many patients as in the previous study had fully controlled blood pressure in spite of the new policy of co-payment. Health education and patient counselling along with availability of free drug could have contributed to improve adherence to antihypertensive drugs. Physicians managing hypertensive patients should pay attention not only to adequate dosing and appropriate combination of drugs but also to health education and patient counselling.
评估在抗高血压药物支付政策发生变化的情况下,接受治疗的高血压患者目前抗高血压药物的使用模式和血压控制情况,并与之前在同一环境下药物免费时的研究进行比较。
对在国际热带农业研究所医疗诊所接受随访的高血压患者进行横断面研究。
对116名年龄为50.9±8.6岁的连续高血压患者进行了研究。82名(70.7%)患者的血压在治疗中得到完全控制,而15名(12.9%)患者完全未得到控制。仅收缩压得到控制的有14名(12.1%),仅舒张压得到控制的有5名(4.3%)。收缩压为133.4±14.0(106 - 186)mmHg,舒张压为83.5±9.1(59 - 110)mmHg。盐的摄入量与血压控制相关且可预测血压控制情况,r = 0.336,r² = 3.383,p = 0.001。药物使用频率:利尿剂79.8%,钙通道阻滞剂(CCB)51.8%,α-甲基多巴21.9%,血管紧张素转换酶抑制剂17.5%,β-受体阻滞剂15.8%,血管扩张剂1.8%,哌唑嗪0.9%。
在本研究中,尽管有新的共付政策,但血压得到完全控制的患者数量是之前研究的两倍。健康教育、患者咨询以及免费药物的提供可能有助于提高抗高血压药物的依从性。管理高血压患者的医生不仅应关注药物的适当剂量和合理组合,还应关注健康教育和患者咨询。