Department of Clinical Pharmacology, Medical University of Bialystok, Waszyngtona 15A, 15-274 Bialystok, Poland.
Physiol Behav. 2013 Jun 13;118:171-7. doi: 10.1016/j.physbeh.2013.05.002. Epub 2013 May 12.
Long chain n-3 fatty acids, especially eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) may slow cognitive decline. DHA plays an important role in neural function and decreased plasma DHA are associated with cognitive decline in healthy elderly adults and in patients with Alzheimer's disease. In this study we tested a hypothesis that DHA protects cognitive functions of male Wistar rats against negative impact of prolonged restraint stress. Specifically, we attempted to characterize the preventive action of prolonged treatment with DHA enriched preparation (daily dose of DHA: 300mg/kg, p.o. for 21days) in comparison with positive control (fluoxetine: 10mg/kg daily, p.o. for 21days) against an impairment caused by chronic restraint stress (2h daily for 21days) on recognition memory tested in a object recognition task and on the spatial working memory tested in Morris water maze. We found that administration of DHA enriched preparation prevented deleterious effects of chronic restraint stress both on recognition (p<0.01) and on the working spatial memory (p<0.001).
长链 n-3 脂肪酸，尤其是二十碳五烯酸 (EPA) 和二十二碳六烯酸 (DHA)，可能会减缓认知能力下降。DHA 在神经功能中发挥重要作用，而血浆中 DHA 的减少与健康老年人和阿尔茨海默病患者的认知能力下降有关。在这项研究中，我们检验了一个假设，即 DHA 可以保护雄性 Wistar 大鼠的认知功能，使其免受长期束缚应激的负面影响。具体来说，我们试图描述 DHA 富集制剂（每日 DHA 剂量：300mg/kg，口服 21 天）的预防作用，将其与阳性对照（氟西汀：10mg/kg 每日，口服 21 天）进行比较，以对抗慢性束缚应激（每日 2 小时，持续 21 天）对物体识别任务中的识别记忆和 Morris 水迷宫中的空间工作记忆造成的损伤。我们发现，DHA 富集制剂的给药可以预防慢性束缚应激对识别（p<0.01）和工作空间记忆（p<0.001）的有害影响。
