Department of Chemistry, Anhui Agricultural University, Hefei, Anhui 230036, PR China.
Org Biomol Chem. 2013 Jun 28;11(24):4095-101. doi: 10.1039/c3ob40531a.
An intramolecular cyclization of 2-(gem-dibromovinyl)phenols(thiophenols) to give 2-bromobenzofurans(thiophenes) in the presence of a trace amount of Cu (0.0064 mol%, 25 ppm) has been developed. The reaction provides the desired products in excellent yields under fluoride-free and mild reaction conditions and with a TON (turnover number) of up to 1.5 × 10(4).
发展了一种在痕量铜（0.0064mol%，25ppm）存在下，通过 2-（偕二溴乙烯基）苯酚（噻吩酚）的分子内环化反应得到 2-溴苯并呋喃（噻吩）的方法。该反应在无氟、温和的反应条件下以高达 1.5×10(4)的 TON（转化率）得到高产率的目标产物。
