State Key Laboratory of Fine Chemicals, Dalian University of Technology , Dalian 116023, China.
Org Lett. 2014 Feb 7;16(3):764-7. doi: 10.1021/ol403475v. Epub 2014 Jan 10.
Brønsted acid catalyzed cyclization reactions of 2-amino thiophenols/anilines with β-diketones under oxidant-, metal-, and radiation-free conditions are described. Various 2-substituted benzothiazoles/benzimidazoles are obtained in satisfactory to excellent yields. Different groups such as methyl, chloro, nitro, and methoxy linked on benzene rings were tolerated under the optimized reaction conditions.
本文描述了在无氧化剂、金属和辐射条件下，2-氨基噻酚/苯胺与β-二酮的布朗斯特酸催化环化反应。各种 2-取代的苯并噻唑/苯并咪唑以令人满意至优秀的产率得到。在优化的反应条件下，苯环上连接的不同基团，如甲基、氯、硝基和甲氧基，都能被容忍。
