Holliday Alex C, Moody Megan N, Berlingeri-Ramos Alma
Department of Internal Medicine, The University of Texas Medical Branch at Galveston, Galveston, TX, USA.
Skin Therapy Lett. 2013 Mar-Apr;18(3):4-9.
Methotrexate has been used for over half a century to treat a wide spectrum of skin conditions. It is a valuable steroid sparing agent, preventing protracted steroid courses and their undesirable side effects. While many alternative therapies exist and continue to emerge to treat these dermatologic conditions, the long history, affordability, and relative safety associated with methotrexate ensure its enduring utility. Further, ongoing research focusing on the pharmacogenetic properties of the drug may allow for more effective and targeted therapeutic strategies.
甲氨蝶呤已被用于治疗多种皮肤病超过半个世纪。它是一种有价值的类固醇节约剂，可防止长期使用类固醇疗程及其不良副作用。虽然存在并不断涌现出许多替代疗法来治疗这些皮肤病，但甲氨蝶呤的悠久历史、可负担性和相对安全性确保了其持久的效用。此外，针对该药物的药物遗传学特性的持续研究可能会带来更有效和有针对性的治疗策略。
