Li Wen, Gan Chen, Lv Yue, Wang Shanghu, Cheng Huaidong
Department of Oncology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Medicine (Baltimore). 2017 Mar;96(13):e6514. doi: 10.1097/MD.0000000000006514.
This study aimed to investigate prospective memory impairment in patients with breast cancer with different expression of hormone receptors, including the estrogen receptor (ER) and the progesterone receptor (PR).A total of 120 patients with breast cancer who underwent chemotherapy following surgery were divided into 2 groups. The A group included 60 patients with ER/PR status, and the B group included 60 patients with ER/PR status. After 6 cycles of postoperative adjuvant chemotherapy, all patients were administered neuropsychological and prospective memory tests, such as the Mini-Mental State Examination (MMSE), verbal fluency test (VFT), and digit span test (DST), as well as examination of event-based prospective memory (EBPM) and time-based prospective memory (TBPM).As the neuropsychological background test results showed, there were no significant differences in MMSE, DST, and TBPM scores (*:P > 0.05) between patients with breast cancer in the ER/PR and ER/PR groups, while the VFT and EBPM scores were significantly greater in patients with breast cancer with ER/PR status than in those with ER/PR status (**: P < 0.01), indicating that patients with ER/PR status have significant impairment in EBPM, although not in TBPM.The results of the present study indicate that different hormone receptor expression in patients with breast cancer may be associated with heterogeneity of chemotherapy-induced prospective memory impairment.
本研究旨在调查激素受体（包括雌激素受体（ER）和孕激素受体（PR））表达不同的乳腺癌患者的前瞻性记忆损害情况。共有120例术后接受化疗的乳腺癌患者被分为2组。A组包括60例ER/PR状态的患者，B组包括60例ER/PR状态的患者。术后辅助化疗6个周期后，对所有患者进行神经心理学和前瞻性记忆测试，如简易精神状态检查表（MMSE）、语言流畅性测试（VFT）和数字广度测试（DST），以及基于事件的前瞻性记忆（EBPM）和基于时间的前瞻性记忆（TBPM）检查。神经心理学背景测试结果显示，ER/PR和ER/PR组的乳腺癌患者在MMSE、DST和TBPM评分上无显著差异（*：P>0.05），而ER/PR状态的乳腺癌患者的VFT和EBPM评分显著高于ER/PR状态的患者（**：P<0.01），表明ER/PR状态的患者在EBPM方面有显著损害，尽管在TBPM方面没有。本研究结果表明，乳腺癌患者不同的激素受体表达可能与化疗引起的前瞻性记忆损害的异质性有关。
