缺氧对皮肤气体和呼出气体中一氧化氮（NO）的影响。
Effects of Hypoxia on Nitric Oxide (NO) in Skin Gas and Exhaled Air.
作者信息
Ohkuwa Tetsuo, Mizuno Tatsuo, Kato Yuji, Nose Kazutoshi, Itoh Hiroshi, Tsuda Takao
机构信息
Department of Life and Materials Engineering, Nagoya Institute of Technology, Showa-ku, Nagoya, Japan;
出版信息
Int J Biomed Sci. 2006 Sep;2(3):279-83.
This study confirmed the effects of hypoxia on nitric oxide (NO) concentrations in skin gas and exhaled air. NO concentrations in skin gas and exhaled air were measured by a chemiluminescence analyzer. Arterial oxygen saturation (SpO2) of the right forefinger was determined using an oxygen saturation monitor. The M ± SEM of NO concentrations in skin gas at 20.93% (control), 15.1% and 14.8% oxygen concentrations were 23.7 ± 3.6, 32.3 ± 4.7 and 36.2 ± 5.2 ppb, respectively. M ± SEM of NO concentrations in exhaled air at 20.93% (control), 15.1%, and 14.8% were 25.0 ± 5.1, 35.01 ± 5.6 and 44.9 ± 7.2 ppb, respectively. There was no significant difference in NO concentration at the absolute value of skin gas and exhaled air between normoxia and hypoxia. But significant increase was found at relative changes in skin gas at 15.1% (p<0.01) and 14.8% (p<0.01) oxygen content compared with control. Significant increase was also found at relative changes in exhaled air at 15.1% (p<0.01) and 14.8% (p<0.01) oxygen content compared with control. In conclusion, we confirmed that exposure to hypoxia elicits an increase in NO concentrations at relative changes of skin gas and exhaled air compared to normoxia.
本研究证实了缺氧对皮肤气体和呼出气体中一氧化氮（NO）浓度的影响。使用化学发光分析仪测量皮肤气体和呼出气体中的NO浓度。使用氧饱和度监测仪测定右手食指的动脉血氧饱和度（SpO2）。在氧气浓度为20.93%（对照）、15.1%和14.8%时，皮肤气体中NO浓度的M±SEM分别为23.7±3.6、32.3±4.7和36.2±5.2 ppb。在氧气浓度为20.93%（对照）、15.1%和14.8%时，呼出气体中NO浓度的M±SEM分别为25.0±5.1、35.01±5.6和44.9±7.2 ppb。在常氧和缺氧状态下，皮肤气体和呼出气体中NO浓度的绝对值无显著差异。但与对照相比，在氧气含量为15.1%（p<0.01）和14.8%（p<0.01）时，皮肤气体的相对变化中发现显著增加。与对照相比，在氧气含量为15.1%（p<0.01）和14.8%（p<0.01）时，呼出气体的相对变化中也发现显著增加。总之，我们证实，与常氧相比，暴露于缺氧状态会导致皮肤气体和呼出气体的相对变化中NO浓度增加。
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