Scialpi Michele, Franzini Christian, Cavaliere Antonio, Barberini Francesco, Piscioli Irene, Franceschetti Ilaria, Lupattelli Luciano
Department of Surgery Radiology, Odontostomatology Science, Section of Diagnostic and Interventional Radiology, University of Perugia, S. Maria della Misericordia Hospital, S. Andrea delle Fratte, 06156 Perugia, Italy;
Int J Biomed Sci. 2009 Mar;5(1):74-8.
We describe a seven years follow-up of a high risk gastrointestinal stromal tumor in a Meckel's diverticulum in a 68-year-old man with abdominal pain and vomiting. The patient was operated in emergency for peritonitis due to perforation of small intestine and treated with imatinib mesylate. The metastatic progression of the disease demonstrated the value of prognostic indicators (mitotic rate >10/50 high power field, necrosis and 8 cm in maximum diameter) for assessing risk of aggressive behaviour. Computed tomography was a valuable procedure for detection of local recurrence, the distant metastases and for surveillance after surgery in the follow-up. The review of the literature shows that this case has the longest follow up and consents the comparisons of the same neoplasm in other sites most frequent and better described than Meckel's diverticulum.
我们描述了一名68岁腹痛和呕吐男性患者，其梅克尔憩室中高危胃肠道间质瘤的七年随访情况。该患者因小肠穿孔导致腹膜炎接受了急诊手术，并接受甲磺酸伊马替尼治疗。疾病的转移进展证明了预后指标（有丝分裂率>10/50高倍视野、坏死和最大直径8厘米）在评估侵袭性行为风险方面的价值。计算机断层扫描是检测局部复发、远处转移以及术后随访监测的有价值的检查方法。文献综述表明，该病例的随访时间最长，有助于与其他部位更常见且描述更完善的同一肿瘤进行比较，而梅克尔憩室的情况则相对少见。
