Smith-Norowitz Tamar A, Josekutty Joby, Silverberg Jonathan I, Lev-Tov Hadar, Norowitz Yitzchok M, Kohlhoff Stephan, Nowakowski Maja, Durkin Helen G, Bluth Martin H
Departments of Pediatrics, Center for Allergy and Asthma Research, S.U.N.Y. Downstate Medical Center, Brooklyn, New York, USA;
Int J Biomed Sci. 2009 Dec;5(4):353-8.
The production of IgE specific to different viruses (HIV-1, Parvovirus B19, RSV), and the ability for IgE anti-HIV-1 to suppress HIV-1 production in vitro, strongly suggest an important role for IgE and/or anti viral specific IgE in viral pathogenesis. Previous studies in our laboratory were the first to report the presence of IgE anti-varicella zoster virus (VZV) in an adolescent patient with shingles. However, the presence and long term persistence of IgE anti VZV antibodies has not been studied in adults. The presence of serum IgE in addition to IgE and IgG anti-VZV antibody in sera were studied in children (N=12) (0-16 y/o) and adults (N=9) (32-76 y/o) with either a past history of (wild type) chicken pox (N=7 children, 9 adults) or 5 years after vaccination with varicella zoster (N=2 children) (Varicella virus vaccine live, Oka/Merck), as well as in non-infected subjects (N=3 children). Of the patients who had a positive history of chicken pox 13 of 16 (81%) contained IgE anti-VZV antibodies; they were both serum IgEHi (>100 IU/ml) and IgELo (<100 IU/ml). Of the patients who were vaccinated, IgE anti-VZV antibodies were undetected. In contrast, serum from the patients without a history of chicken pox or vaccination did not make either IgE or IgG anti-VZV antibodies. This is the first demonstration of the existence of IgE anti-VZV antibodies, and its long-term persistence in serum of previously infected subjects. Future studies regarding the functional role of anti-viral IgE and its relationship to VZV are warranted.
针对不同病毒（HIV-1、细小病毒B19、呼吸道合胞病毒）的IgE产生，以及IgE抗HIV-1在体外抑制HIV-1产生的能力，强烈提示IgE和/或抗病毒特异性IgE在病毒发病机制中起重要作用。我们实验室先前的研究首次报道了一名患有带状疱疹的青少年患者体内存在抗水痘带状疱疹病毒（VZV）的IgE。然而，尚未在成人中研究抗VZV抗体的存在及长期持续性。我们研究了患有（野生型）水痘病史（7名儿童，9名成人）或接种水痘带状疱疹疫苗5年后（2名儿童）（水痘病毒活疫苗，Oka/默克）的儿童（N = 12）（0 - 16岁）和成人（N = 9）（32 - 76岁）血清中除IgE和IgG抗VZV抗体外的血清IgE的存在情况，以及未感染受试者（3名儿童）。在有水痘阳性病史的患者中，16名中有13名（81%）含有抗VZV抗体IgE；这些患者既有血清IgE高（>100 IU/ml）的，也有血清IgE低（<100 IU/ml）的。在接种疫苗的患者中，未检测到抗VZV抗体IgE。相比之下，没有水痘病史或疫苗接种史的患者血清未产生抗VZV抗体IgE或IgG。这是首次证明抗VZV抗体IgE的存在及其在既往感染受试者血清中的长期持续性。有必要对抗病毒IgE的功能作用及其与VZV的关系进行进一步研究。
