从心外膜脂肪组织到易损冠状动脉斑块。
From the epicardial adipose tissue to vulnerable coronary plaques.
作者信息
Echavarría-Pinto Mauro, Hernando Lorenzo, Alfonso Fernando
机构信息
Mauro Echavarría-Pinto, Fernando Alfonso, Interventional Cardiology, Cardiovascular Institute, Hospital Clinico San Carlos, 28040 Madrid, Spain.
出版信息
World J Cardiol. 2013 Apr 26;5(4):68-74. doi: 10.4330/wjc.v5.i4.68.
Abstract
Thin cap fibroatheromas (TCFAs) are thought to be the most common underlying substrate in patients suffering acute coronary thrombotic events. Recently, an interesting association between TCFAs and a particular depot of visceral fat called epicardial adipose tissue (EAT) has been suggested. In this article, we discuss some basic and clinical aspects of this association and then briefly review some of the pathophysiological characteristics attributed to EAT that explain why this particular depot of fat has been attracting the attention of the cardiological scientific community in recent years. Finally we discuss the value of optical coherence tomography in the diagnosis of TCFAs and the role of multislice computed tomography to assess EAT.
摘要
薄帽纤维粥样斑块（TCFAs）被认为是急性冠状动脉血栓形成事件患者中最常见的潜在病变基础。最近，有人提出TCFAs与一种称为心外膜脂肪组织（EAT）的特定内脏脂肪储存库之间存在有趣的关联。在本文中，我们讨论了这种关联的一些基础和临床方面，然后简要回顾了归因于EAT的一些病理生理特征，这些特征解释了为什么这种特殊的脂肪储存库近年来一直吸引着心脏病学科学界的关注。最后，我们讨论了光学相干断层扫描在TCFAs诊断中的价值以及多层螺旋计算机断层扫描在评估EAT中的作用。
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本文引用的文献
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Int J Cardiovasc Imaging. 2013 Jan;29(1):13-21. doi: 10.1007/s10554-012-0043-3. Epub 2012 Apr 21.
2
How to interpret epicardial adipose tissue as a cause of coronary artery disease: a meta-analysis.如何将心外膜脂肪组织解读为冠状动脉疾病的一个病因：一项荟萃分析。
Coron Artery Dis. 2012 Jun;23(4):227-33. doi: 10.1097/MCA.0b013e328351ab2c.
3
The impact of epicardial fat volume on coronary plaque vulnerability: insight from optical coherence tomography analysis.心外膜脂肪体积对冠状动脉斑块易损性的影响：光学相干断层成像分析的见解。
Eur Heart J Cardiovasc Imaging. 2012 May;13(5):408-15. doi: 10.1093/ehjci/jes022. Epub 2012 Jan 30.
4
Epicardial fat: from the biomolecular aspects to the clinical practice.心外膜脂肪：从生物分子角度到临床实践。
Int J Biochem Cell Biol. 2011 Dec;43(12):1651-4. doi: 10.1016/j.biocel.2011.09.006. Epub 2011 Sep 28.
5
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