Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama 700-8558, Japan.
Diagn Pathol. 2013 May 15;8:81. doi: 10.1186/1746-1596-8-81.
D cyclins positively regulate the cell cycle and mediate the pathogenesis of some lymphomas. Cyclin D1 overexpression is the hallmark of mantle cell lymphoma, whereas cyclins D2 and D3 are reportedly not as specific to certain lymphomas as cyclin D1. In this study, cyclin D2 was found to be overexpressed in 98% of de novo CD5-positive diffuse large B-cell lymphomas (DLBCLs) (50/51) and in 28% of CD5-negative DLBCLs (14/51). A statistically significant difference was observed between these two groups (p<0.0001). In contrast, no statistical difference was found in the cyclin D3 expression between CD5-positive (18/51) and CD5-negative (24/51) DLBCLs (p=0.23). Based on these findings, cyclin D2 is therefore considered to be closely associated with de novo CD5-positive DLBCLs. This insight may be useful for overcoming the inferior survival of this aggressive lymphoma.
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D 型细胞周期蛋白正向调节细胞周期，并介导某些淋巴瘤的发病机制。Cyclin D1 的过表达是套细胞淋巴瘤的标志，而 Cyclin D2 和 D3 据报道不如 Cyclin D1 那样特异性地针对某些淋巴瘤。在这项研究中，发现 Cyclin D2 在 98%的新发 CD5 阳性弥漫性大 B 细胞淋巴瘤（DLBCL）（50/51）和 28%的 CD5 阴性 DLBCL（14/51）中过表达。这两组之间观察到统计学上的显著差异（p<0.0001）。相比之下，在 CD5 阳性（18/51）和 CD5 阴性（24/51）DLBCL 之间，Cyclin D3 的表达没有统计学差异（p=0.23）。基于这些发现，Cyclin D2 因此被认为与新发的 CD5 阳性 DLBCL 密切相关。这一见解可能有助于克服这种侵袭性淋巴瘤的生存劣势。
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