Chao T C, Park J M, Rhee H, Greager J A
Department of Surgery, University of Illinois College of Medicine, Chicago.
Plast Reconstr Surg. 1990 Aug;86(2):347-51. doi: 10.1097/00006534-199008000-00028.
Merkel cell tumor is an unusual, aggressive malignancy of skin that has been considered to be derived from cutaneous Merkel cells. We are reporting a case of Merkel cell tumor overlying the left scapula with metastases to the thoracic spine and pleura. The tumor was found incidentally in a 23-year-old pregnant black woman. The tumor recurred locally 5 months after initial wide excision. Subsequently, a second wide excision of the recurrent tumor with ipsilateral axillary dissection was performed. The course of the disease was complicated by local recurrence and formation of distant metastases to pleura and spine. At the end-stage of the disease, the patient was found to have a cardiac murmur, and echocardiography revealed a mass in the anterior wall of the right ventricle that was suspicious for a metastatic lesion. The patient expired from extensive distant metastases 23 months after diagnosis.
默克尔细胞癌是一种罕见的、侵袭性皮肤恶性肿瘤，一直被认为起源于皮肤默克尔细胞。我们报告一例发生于左肩胛骨上方的默克尔细胞癌，已转移至胸椎和胸膜。该肿瘤偶然发现于一名23岁的怀孕黑人女性。肿瘤在初次广泛切除术后5个月局部复发。随后，对复发性肿瘤进行了第二次广泛切除并进行了同侧腋窝淋巴结清扫。疾病过程因局部复发和胸膜及脊柱远处转移的形成而复杂化。在疾病终末期，发现患者有心脏杂音，超声心动图显示右心室前壁有一肿块，怀疑为转移瘤。患者在诊断后23个月因广泛远处转移而死亡。
