Regan Daniel P, Dubielzig Richard R, Zeiss Caroline J, Charles Brad, Hoy Sarah S, Ehrhart E J
Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.
Vet Ophthalmol. 2013 Jul;16 Suppl 1:87-93. doi: 10.1111/vop.12056. Epub 2013 May 15.
We describe the clinical, histological, and immunohistochemical features of primary intraocular primitive neuroectodermal tumors in eight dogs. Four of eight tumors exhibited histological features similar to human retinoblastomas characterized by Flexner-Wintersteiner rosettes, and fleurettes, and demonstrated variable immunoreactivity for retinal markers opsin, S-antigen (S-Ag) and interphotoreceptor retinoid-binding protein (IRBP). All dogs with tumors displaying histological and immunohistochemical features of retinal differentiation were ≤2 years of age. All tumors diagnosed as medulloepitheliomas (n = 4) did not display histological and immunohistochemical features of retinal differentiation and were present in dogs 7 years or older. Age of onset, in conjunction with immunohistochemistry for opsin, S-Ag, and IRBP, is an important aid in the differentiation of primary, primitive neuroectodermal tumors arising within the canine ciliary body, retina, and optic papilla.
我们描述了8只犬原发性眼内原始神经外胚层肿瘤的临床、组织学和免疫组化特征。8只肿瘤中有4只表现出与人类视网膜母细胞瘤相似的组织学特征，其特征为Flexner-Wintersteiner菊形团和小花，并对视网膜标志物视蛋白、S抗原（S-Ag）和光感受器间类视黄醇结合蛋白（IRBP）表现出不同的免疫反应性。所有肿瘤具有视网膜分化的组织学和免疫组化特征的犬年龄均≤2岁。所有诊断为髓上皮瘤（n = 4）的肿瘤均未表现出视网膜分化的组织学和免疫组化特征，且存在于7岁或7岁以上的犬中。发病年龄，结合对视蛋白、S-Ag和IRBP的免疫组化检查，有助于鉴别犬睫状体、视网膜和视乳头内发生的原发性原始神经外胚层肿瘤。
