Dermatologie pédiatrique, Hôpital Necker - Enfants Malades, Paris, France.
J Eur Acad Dermatol Venereol. 2013 Nov;27(11):1426-32. doi: 10.1111/jdv.12180. Epub 2013 May 16.
The notion of individual burden, associated with a disease, has been introduced to determine the 'disability' in the broadest sense (psychological, social, economic and physical). Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases with an estimated prevalence of 5%-30% in children.
To develop and validate a specific questionnaire which assess the burden of families of children with AD: the Atopic dermatitis Burden Scale (ABS).
Items for inclusion in ABS were initially generated from a literature review and a verbatim report from parents whose child had AD. ABS was refined via item reduction according to interquestion correlations, consensus among experts and exploratory factor analysis. Internal consistency was determined by calculating the Cronbach's α, concurrent validity by calculating the correlation between ABS and the Short-Form 12 items. Discriminant validity was analysed according to the severity degrees of AD assessed by Patient-Oriented SCORing index of Atopic Dermatitis (PO-SCORAD).
From an initial list of 29 items, ABS was reduced to a 14-item questionnaire, grouped into four dimensions based on the exploratory factor analysis. Construct validity was demonstrated and ABS showed good internal coherence (Cronbach's α: 0.78). ABS was significantly correlated to the mental dimension of Short-Form 12 (r = -0.49), but it was not correlated to the physical dimension (r = 0.04). ABS scores were significantly different according to the severity degrees of AD, with higher ABS score in parents whose child had severe AD.
The ABS questionnaire is a validated tool for assessing the burden of families of children with AD. An implementation of a prospective study is planned to estimate sensitivity to change and to confirm its domain structure in larger samples.
个体负担的概念与疾病相关联，旨在从广义上（心理、社会、经济和身体）确定“残疾”。特应性皮炎（AD）是最常见的慢性炎症性皮肤病之一，估计儿童患病率为 5%-30%。
开发和验证专门评估 AD 患儿家庭负担的问卷：特应性皮炎负担量表（ABS）。
ABS 的纳入项目最初源自文献回顾和患有 AD 的患儿父母的逐字报告。根据问题间相关性、专家共识和探索性因子分析，通过项目删减对 ABS 进行了优化。采用 Cronbach's α 计算内部一致性，采用 ABS 与 12 项简明健康调查问卷（Short-Form 12）的相关性计算评估同时效度。根据特应性皮炎患者导向评分指数（Patient-Oriented SCORing index of Atopic Dermatitis，PO-SCORAD）评估的 AD 严重程度分析判别效度。
从最初的 29 项清单中，ABS 被简化为一个 14 项的问卷，根据探索性因子分析分为四个维度。验证了结构效度，ABS 显示出良好的内部一致性（Cronbach's α：0.78）。ABS 与 Short-Form 12 的心理维度显著相关（r=-0.49），但与生理维度不相关（r=0.04）。根据 AD 的严重程度，ABS 评分存在显著差异，患有严重 AD 的患儿的父母的 ABS 评分更高。
ABS 问卷是评估 AD 患儿家庭负担的有效工具。计划实施前瞻性研究以估计其对变化的敏感性，并在更大的样本中验证其领域结构。
