Apter A, van Praag H M, Plutchik R, Sevy S, Korn M, Brown S L
Bar Ilan University, Israel.
Psychiatry Res. 1990 May;32(2):191-9. doi: 10.1016/0165-1781(90)90086-k.
Serotonin abnormalities appear to be related to a variety of psychopathological dimensions such as anxiety, depressed mood, impulsivity, and aggression dysregulation. We hypothesized that the psychopathological dimensions related to serotonin would be significantly intercorrelated since they seem to have a common biological basis. Sixty psychiatric inpatients were examined on a series of psychometric tests measuring suicidality, violence potential, impulsivity, depressive mood, and anxiety. The scores on all of these measures tended to be significantly correlated with one another. These findings support the additional hypothesis that biological markers may be more closely related to basic psychological dimensions than to nosological categories.
血清素异常似乎与多种精神病理学维度相关，如焦虑、抑郁情绪、冲动和攻击失调。我们假设，与血清素相关的精神病理学维度会显著相互关联，因为它们似乎有共同的生物学基础。对60名精神科住院患者进行了一系列心理测量测试，测量自杀倾向、暴力潜能、冲动、抑郁情绪和焦虑。所有这些测量的分数往往彼此显著相关。这些发现支持了另一个假设，即生物标志物可能与基本心理维度的关系比与疾病分类的关系更密切。
