Kawamoto Shinichiro, Hatanaka Kazuo, Imakita Masami, Tamaki Toshiharu
Department of Internal Medicine, Rinku General Medical Center, Japan.
Intern Med. 2013;52(10):1107-10. doi: 10.2169/internalmedicine.52.9432. Epub 2013 May 15.
A 60-year-old myelodysplastic syndrome patient underwent tandem cord blood transplantation. The primary cord blood graft was rejected, and human herpesvirus 6 (HHV6) encephalitis developed after engraftment of secondary cord blood. Polyuria and adipsic hypernatremia were observed during treatment of the encephalitis. The patient died of bacteremia caused by methicillin-resistant Streptococcus epidermis. HHV6 infection in the posterior pituitary was confirmed on autopsy, as was infection of the hippocampus, but not of the hypothalamus. This is the first case report of central diabetes insipidus caused by an HHV6 posterior pituitary infection demonstrated on a pathological examination.
一名60岁的骨髓增生异常综合征患者接受了串联脐带血移植。首次脐带血移植物被排斥，二次脐带血植入后发生了人疱疹病毒6型（HHV6）脑炎。在脑炎治疗期间观察到多尿和无渴感高钠血症。患者死于耐甲氧西林表皮葡萄球菌引起的菌血症。尸检证实垂体后叶存在HHV6感染，海马体也有感染，但下丘脑未感染。这是首例经病理检查证实由HHV6垂体后叶感染引起中枢性尿崩症的病例报告。
