Shaker Marcus S, Hsu Derek, Gruenberg David A
aSection of Allergy, Asthma, and Immunology, Department of Pediatrics, Children's Hospital at Dartmouth, Lebanon bGeisel School of Medicine, Hanover, New Hampshire cSection of Allergy and Immunology, Lahey Clinic, Burlington, Massachusetts, USA.
Curr Opin Pediatr. 2013 Oct;25(5):629-34. doi: 10.1097/MOP.0b013e328361a496.
Allergic reactions to stinging insects may be unexpected, frightening, and severe. A clear understanding of recent advances in the field facilitates appropriate care of children who experience severe reactions to hymenoptera stings.
Recent investigations have underscored the importance of appropriate patient selection for potentially life-saving venom immunotherapy. Venom immunotherapy is effective in preventing future anaphylaxis from hymenoptera stings. Immunotherapy is indicated for patients with a history of anaphylaxis. Children who develop large local swelling or strictly cutaneous systemic reactions generally do not require immunotherapy. Component resolved diagnostic testing has been investigated to clarify the possibility of multiple venom allergies in patients with sensitization to multiple venoms.
Rapid recognition and treatment of anaphylaxis are critical. Subsequent education about avoiding future stings and attention to emergency preparedness with appropriate prescription of self-injectable epinephrine is important. Referral of patients who have experienced venom-associated anaphylaxis for possible venom immunotherapy can prevent future severe episodes of anaphylaxis resulting from stings.
对昆虫叮咬的过敏反应可能出人意料、令人恐惧且严重。清楚了解该领域的最新进展有助于对遭受膜翅目昆虫叮咬严重反应的儿童进行适当护理。
近期研究强调了为潜在的救命毒液免疫疗法进行适当患者选择的重要性。毒液免疫疗法可有效预防未来膜翅目昆虫叮咬引起的过敏反应。免疫疗法适用于有过敏反应病史的患者。出现大面积局部肿胀或仅皮肤全身性反应的儿童通常不需要免疫疗法。已对组分分辨诊断检测进行研究,以明确对多种毒液致敏的患者发生多种毒液过敏的可能性。
快速识别和治疗过敏反应至关重要。随后进行关于避免未来被叮咬的教育,并通过适当开具自动注射肾上腺素处方关注应急准备也很重要。将经历过与毒液相关过敏反应的患者转诊接受可能的毒液免疫疗法,可预防未来因叮咬导致的严重过敏发作。