使用 Fe(NO3)3·9H2O/TEMPO/NaCl 作为催化剂对吲哚甲醇进行有氧氧化。

Aerobic oxidation of indole carbinols using Fe(NO3)3·9H2O/TEMPO/NaCl as catalysts.

机构信息

Key Laboratory of Green Chemistry and Chemical Process, Department of Chemistry, East China Normal University, 3663 North Zhongshan Lu, Shanghai 200062, PR China.

出版信息

Org Biomol Chem. 2013 Jul 7;11(25):4186-93. doi: 10.1039/c3ob40226f.

DOI:10.1039/c3ob40226f

PMID:23677005

Abstract

A practical aerobic oxidation of indole carbinols using Fe(NO3)3·9H2O/TEMPO/NaCl in DCE at room temperature and atmospheric pressure of oxygen affording aldehydes or ketones in good to excellent yields was developed. Furthermore, when using the industrially favored solvent toluene instead of DCE and air instead of pure oxygen, this protocol also works smoothly, demonstrating its high potential for possible industrial application.

摘要

采用 Fe(NO3)3·9H2O/TEMPO/NaCl 在 DCE 中室温、常压下氧气条件下实现了吲哚醇的实用有氧氧化，以良好至优异的收率得到了醛或酮。此外，当使用工业上优选的溶剂甲苯代替 DCE，以及空气代替纯氧时，该方法也能顺利进行，这表明它具有很大的潜在工业应用价值。