Division of Neurology, Kanagawa Children's Medical Center, Mutsukawa 2-138-4, Minami-ku, Yokohama, Kanagawa, 232-8555, Japan.
Pediatr Radiol. 2013 Oct;43(10):1400-3. doi: 10.1007/s00247-013-2661-x. Epub 2013 May 16.
A stroke-like episode is a core symptom in mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS). Proton magnetic resonance spectroscopy (1H-MRS) is useful in the diagnosis of mitochondrial diseases. We report an 8-year-old girl with MELAS, presenting with a seizure and blindness. 1H-MRS showed a strikingly elevated lactate peak in the right occipital region, where no abnormal signals appeared on either T2-W or diffusion-weighted MRI. She recovered completely within a day. We describe this mild clinical condition with abnormal lactate peak in normal-appearing gray matter as a transient ischemic attack-like episode in MELAS.
发作样事件是线粒体肌病、脑病、乳酸酸中毒和卒中样发作（MELAS）的核心症状。质子磁共振波谱（1H-MRS）有助于线粒体疾病的诊断。我们报告了一例 8 岁 MELAS 女孩，表现为癫痫发作和失明。1H-MRS 显示右侧枕叶区域的乳酸峰显著升高，而 T2-W 或弥散加权 MRI 上均无异常信号。她在一天内完全恢复。我们将这种在外观正常的灰质中出现异常乳酸峰的轻度临床情况描述为 MELAS 中的短暂性脑缺血发作样事件。
