Franch M A, Moreno J J, Castell M, Queralt J
Department of Physiologycal Sciences, School of Pharmacy, Barcelona University, Spain.
Res Exp Med (Berl). 1990;190(3):213-8. doi: 10.1007/pl00020024.
In the present study we have determined if renal damage occurs with adjuvant arthritis (AA). As a sensitive indicator of renal injury in tubular cells, urinary N-acetyl-beta-D-glucosaminidase (NAG) was measured at predetermined times after arthritis induction. Urinary protein, sodium and potassium excretion were also evaluated. NAG levels in arthritic animals were higher than those in healthy ones from day 12 after induction and the levels remained high during the study period. A significant positive correlation was noted between urinary NAG excretion and disease severity reflected by hind paw edema. Protein excretion also increased in arthritic animals but there was no correlation between urinary protein, NAG levels, and degree of inflammation. Changes in urine sodium and potassium levels did not reach statistical significance. Thus, we can conclude that some renal damage occurred in this experimental model of chronic inflammation.
在本研究中，我们确定了佐剂性关节炎（AA）是否会导致肾损伤。作为肾小管细胞肾损伤的敏感指标，在诱导关节炎后的预定时间测量尿N-乙酰-β-D-氨基葡萄糖苷酶（NAG）。还评估了尿蛋白、钠和钾排泄。诱导后第12天起，关节炎动物的NAG水平高于健康动物，且在研究期间一直保持较高水平。尿NAG排泄与后爪水肿所反映的疾病严重程度之间存在显著正相关。关节炎动物的蛋白排泄也增加，但尿蛋白、NAG水平与炎症程度之间无相关性。尿钠和钾水平的变化未达到统计学意义。因此，我们可以得出结论，在这个慢性炎症实验模型中发生了一些肾损伤。
