尿N-乙酰-β-D-氨基葡萄糖苷酶活性升高在慢性镉中毒中的意义

Significance of elevated urinary N-acetyl-beta-D-glucosaminidase activity in chronic cadmium poisoning.

作者信息

Nogawa K, Yamada Y, Kido T, Honda R, Ishizaki M, Tsuritani I, Kobayashi E

出版信息

Sci Total Environ. 1986 Sep;53(3):173-8. doi: 10.1016/0048-9697(86)90130-0.

Abstract

N-Acetyl-beta-D-glucosaminidase (NAG) activity and beta 2-microglobulin (beta 2-m) concentration were measured in the urine of inhabitants of a cadmium-polluted area (Cd), including patients with, or suspected, "itai-itai" disease and control subjects. Urinary NAG activity increased with increasing beta 2-m concentration up to about 100 U/g creatinine; above this value the NAG activity did not increase with increasing beta 2-m concentration. Urinary NAG activity thus represents another useful indicator of renal tubular damage caused by Cd poisoning since the mechanisms for the excretion of NAG and beta 2-m into urine are thought to be different.

摘要

在一个镉污染地区（Cd）的居民尿液中，测量了N-乙酰-β-D-氨基葡萄糖苷酶（NAG）活性和β2-微球蛋白（β2-m）浓度，这些居民包括患有或疑似患有“痛痛病”的患者以及对照对象。尿NAG活性随着β2-m浓度的增加而增加，直至约100 U/g肌酐；超过该值后，NAG活性不再随β2-m浓度的增加而增加。由于NAG和β2-m排泄到尿液中的机制被认为不同，因此尿NAG活性是镉中毒引起肾小管损伤的另一个有用指标。