法莫替丁对大鼠胃黏液的影响。

Effects of famotidine on gastric mucus of the rat.

作者信息

Eleftheriadis E, Kotzampassi K, Tzioufa V, Karamouzis M, Aletras H

机构信息

Department of Surgery, University of Thessaloniki, Greece.

出版信息

Res Exp Med (Berl). 1990;190(3):219-22. doi: 10.1007/pl00020025.

DOI:10.1007/pl00020025

PMID:2367747

Abstract

The influence of famotidine on the production of gastric mucus was studied at experimental level. We measured the quantity of the intracellular mucus, the surface adherent mucus gel thickness, and the biosynthesis of prostaglandin E2 (PGE2) by the rat gastric mucosa, in pretreated animals. Both the intracellular mucus accumulation and the adherent mucus gel thickness revealed a highly statistically significant increase (P less than 0.0002). PGE2 assay showed that famotidine also led to a statistically significant increase (P = 0.02) of PGE2 in treated versus control animals. These findings raise the question of whether despite its common antisecretory pathway of action this H2-receptor antagonist could play a role in the protection of gastric mucosa. Further research is necessary to determine this.

摘要

在实验水平上研究了法莫替丁对胃黏液产生的影响。我们测量了预处理动物的大鼠胃黏膜细胞内黏液量、表面附着黏液凝胶厚度以及前列腺素E2（PGE2）的生物合成。细胞内黏液积累和附着黏液凝胶厚度均显示出具有高度统计学意义的增加（P < 0.0002）。PGE2检测表明，与对照动物相比，法莫替丁还导致治疗动物的PGE2有统计学意义的增加（P = 0.02）。这些发现提出了一个问题，即尽管这种H2受体拮抗剂具有常见的抗分泌作用途径，但它是否能在胃黏膜保护中发挥作用。需要进一步研究来确定这一点。