Department of Oncology Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
J Surg Oncol. 2013 Jul;108(1):34-41. doi: 10.1002/jso.23339. Epub 2013 May 15.
There has been little research on the perioperative D-dimer levels in oesophageal cancer patients. Plasma D-dimer levels can be used to predict the outcome in cancer patients.
A cancer group of 66 oesophageal cancer patients and a control group of 12 patients with benign disease were enrolled in this cohort study. The plasma D-dimer levels during the pre-operation and 3rd and 9th day post-operation periods were prospectively examined and analysed between the two groups. Plasma D-dimer levels were also compared with the clinicopathological characteristics and 3-year survival of the oesophageal cancer patients.
Plasma D-dimer levels increased in both groups after surgery, but they were significantly higher in the cancer group. In oesophageal cancer patients, pre-operation plasma D-dimer levels were significantly higher in TNM stage IV patients. Perioperative plasma D-dimer levels significantly increased after surgery, and the survival was shortened in those patients whose D-dimer levels on the 3rd and 9th post-operative day above the median. In addition, increased plasma D-dimer levels at the 3rd and 9th days after surgery were influenced by the patient's age.
In oesophageal cancer patients, D-dimer levels increased after surgery, and the increases were associated with poor outcomes.
针对食管癌患者围手术期 D-二聚体水平的研究较少。血浆 D-二聚体水平可用于预测癌症患者的预后。
本队列研究纳入了 66 例食管癌患者的癌症组和 12 例良性疾病患者的对照组。前瞻性检查并分析了两组患者手术前和术后第 3 天和第 9 天的血浆 D-二聚体水平。还比较了血浆 D-二聚体水平与食管癌患者的临床病理特征和 3 年生存率。
手术后两组患者的血浆 D-二聚体水平均升高，但癌症组升高更明显。在食管癌患者中，TNM 分期 IV 期患者的术前血浆 D-二聚体水平显著升高。术后围手术期血浆 D-二聚体水平显著升高，术后第 3 天和第 9 天 D-二聚体水平高于中位数的患者生存时间缩短。此外，术后第 3 天和第 9 天升高的血浆 D-二聚体水平受患者年龄的影响。
在食管癌患者中，D-二聚体水平在手术后升高，且升高与不良预后相关。
