Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Am J Alzheimers Dis Other Demen. 2013 Jun;28(4):327-36. doi: 10.1177/1533317513488925. Epub 2013 May 15.
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by beta-amyloid plaques accumulation and cognitive impairment. Both environmental factors and heritable predisposition have a role in AD. Histamine is a biogenic monoamine that plays a role in several physiological functions, including induction of inflammatory reactions, wound healing, and regeneration. The Histamine mediates its functions via its 4 G-protein-coupled Histamine H1 receptor (H1R) to histamine H1 receptor (H4R). The histaminergic system has a role in the treatment of brain disorders by the development of histamine receptor agonists, antagonists. The H1R and H4R are responsible for allergic inflammation. But recent studies show that histamine antagonists against H3R and regulation of H2R can be more efficient in AD therapy. In this review, we focus on the role of histamine and its receptors in the treatment of AD, and we hope that histamine could be an effective therapeutic factor in the treatment of AD.
阿尔茨海默病（AD）是一种神经退行性疾病，其特征是β-淀粉样斑块积累和认知障碍。环境因素和遗传易感性都在 AD 中起作用。组胺是一种生物单胺，在几种生理功能中发挥作用，包括诱导炎症反应、伤口愈合和再生。组胺通过其 4 种 G 蛋白偶联组胺 H1 受体（H1R）发挥作用，将组胺传递至组胺 H1 受体（H4R）。通过开发组胺受体激动剂和拮抗剂，组胺能系统在治疗脑疾病方面发挥作用。H1R 和 H4R 负责过敏炎症。但最近的研究表明，针对 H3R 的组胺拮抗剂和 H2R 的调节在 AD 治疗中可能更有效。在这篇综述中，我们重点介绍了组胺及其受体在 AD 治疗中的作用，我们希望组胺能成为 AD 治疗的有效治疗因子。
